Oesophageal diseases

Oesophageal diseases are diseases that affect the oesophagus. Oesophageal diseases include Barrett's oesophagus, gastro-oesophageal reflux disease and oesophageal cancer.

Latest Research and Reviews

News and Comment

  • Comments and Opinion | | open

    Dr. Kate Miroshnikova is a bioengineer by training and is currently a postdoctoral EMBO/HFSP fellow at the Max Planck Institute for Biology of Ageing and at the Helsinki Institute of Life Science. She is interested in understanding biomechanical regulation of stem cell fate decisions in health and disease. Kate’s long term scientific interest is to understand how cells and tissues sense, integrate, and adapt their transcriptomes and proteomes to the highly dynamic mechanical environments without compromising structural and genomic integrity.

  • Research Highlights |

    Martincorena, Fowler et al. have characterized the mutational landscape of normal oesophageal tissue during ageing, which has provided important insights into early cancer development.

    • Anna Dart
  • News and Views |

    A minority of patients with gastroesophageal adenocarcinoma derive benefit from immune-checkpoint inhibition (ICI). In a large-cohort phase III study, the nivolumab (1 mg/kg) plus ipilimumab (3 mg/kg) arm (which was based on promising preliminary data from CheckMate 032) was closed owing to unacceptably high levels of mortality and morbidity. Our quest for better biomarkers than programmed cell death 1 ligand 1 (PD-L1) and safer dual ICI strategies must continue.

    • Kazuto Harada
    • , Ahmed A. F. Abdelhakeem
    •  & Jaffer A. Ajani
  • News and Views |

    Chemoprevention for patients with Barrett’s oesophagus remains a controversial topic. Results of the first randomized trial of chemoprevention using a proton pump inhibitor with or without aspirin were recently reported. We highlight strengths and weaknesses in the design of the trial and discuss the clinical implications of the findings.

    • Nisreen S. Husain
    •  & Hashem B. El-Serag