Oedema is the medical term for soft-tissue swelling that results from the abnormal accumulation of interstitial fluid. Oedema can be generalized or organ-specific.

Latest Research and Reviews

  • Reviews |

    Sepsis is the dysregulated systemic inflammatory and immune response to infection that produces organ injury. Septic shock is characterized by persistent hypotension that substantially increases the risk of death. In this Primer, the authors outline the controversies in sepsis and septic shock, including the complex mechanistic factors and management of critically ill patients.

    • Richard S. Hotchkiss
    • , Lyle L. Moldawer
    • , Steven M. Opal
    • , Konrad Reinhart
    • , Isaiah R. Turnbull
    •  & Jean-Louis Vincent
  • Reviews |

    Acute kidney injury (AKI) is highly prevalent in patients admitted to the intensive care unit, and many of these patients also develop concomitant respiratory complications. In this Review, Faubel and Edelstein discuss the traditional and non-traditional complications of AKI, focusing in particular on the pathologic mechanisms that underlie respiratory complications and the mediators of AKI-induced pulmonary inflammation.

    • Sarah Faubel
    •  & Charles L. Edelstein
  • Reviews |

    Perihaematomal oedema (PHO) is an important pathophysiological marker of secondary injury following intracerebral haemorrhage. In this Review, the authors consider PHO in a novel framework and highlight the clinical relevance of the condition, both as a therapeutic target and as a surrogate marker for novel interventions that target secondary injury.

    • Sebastian Urday
    • , W. Taylor Kimberly
    • , Lauren A. Beslow
    • , Alexander O. Vortmeyer
    • , Magdy H. Selim
    • , Jonathan Rosand
    • , J. Marc Simard
    •  & Kevin N. Sheth
  • Reviews |

    In complex regional pain syndromes (CRPS), pain—typically of neuropathic type—in the affected limb is accompanied by a variety of sensory, motor and autonomic signs and symptoms. Treatment for CRPS has been largely adapted from therapies for neuropathic pain states, but a better understanding of CRPS pathologenesis might provide opportunities for mechanism-based treatment. Here, the authors discuss available and emerging mechanism-based treatments in CRPS, including pharmacotherapy targeting central and peripheral sensitization and aberrant inflammatory response; sympathetic ganglion block interventions; and alleviation of symptoms by reversing body perception disturbances.

    • Janne Gierthmühlen
    • , Andreas Binder
    •  & Ralf Baron

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