Nutrient signalling

Nutrient signalling encompasses various cell signalling pathways that are regulated by nutrient availability. Changing nutrient levels activates signalling cascades that modulate fundamental cellular processes including metabolism, proliferation, secretion and autophagy.

Latest Research and Reviews

  • Reviews |

    Cellular metabolism is rewired in proliferating cells to support their increased need for macromolecule biosynthesis. A better understanding of how cells utilize nutrients for biosynthetic pathways and how they overcome the metabolic challenges associated with high proliferation rates can lead to better control of cell proliferation and improved cancer treatments.

    • Jiajun Zhu
    •  & Craig B. Thompson
  • Research |

    Amino acids are required for cell survival and growth. However, the different requirements of amino acid metabolic pathways in normal haematopoiesis and leukaemogenesis have not been explored. Here the authors focus on the transporter of neutral amino acids and show that malignant blood cells rely more on ASCT2-mediated amino acid metabolism than normal cells.

    • Fang Ni
    • , Wen-Mei Yu
    • , Zhiguo Li
    • , Douglas K. Graham
    • , Lingtao Jin
    • , Sumin Kang
    • , Michael R. Rossi
    • , Shiyong Li
    • , Hal E. Broxmeyer
    •  & Cheng-Kui Qu
    Nature Metabolism 1, 390-403
  • Reviews |

    The protein kinase complex mechanistic target of rapamycin complex 1 (mTORC1) is a key cellular nutrient and energy sensor that integrates several inputs to regulate cell growth. Here, the authors discuss the molecular logic of the mTORC1 signalling network and its importance in coupling growth signals to the control of cellular metabolism.

    • Alexander J. Valvezan
    •  & Brendan D. Manning
    Nature Metabolism 1, 321-333
  • Research |

    The target of rapamycin (TOR) kinase, present in all eukaryotes, is a major regulator of growth and metabolism. Using quantitative phosphoproteomics and comprehensive interactome approaches, the authors reveal the TOR signalling network, including potential substrates.

    • Jelle Van Leene
    • , Chao Han
    • , Astrid Gadeyne
    • , Dominique Eeckhout
    • , Caroline Matthijs
    • , Bernard Cannoot
    • , Nancy De Winne
    • , Geert Persiau
    • , Eveline Van De Slijke
    • , Brigitte Van de Cotte
    • , Elisabeth Stes
    • , Michiel Van Bel
    • , Veronique Storme
    • , Francis Impens
    • , Kris Gevaert
    • , Klaas Vandepoele
    • , Ive De Smet
    •  & Geert De Jaeger
    Nature Plants 5, 316-327

News and Comment

  • News and Views |

    Light is a critical environmental factor that influences nutrient uptake in roots and the subsequent use of nutrients, which is necessary to sustain plant growth. The positive effect of red light on phosphorus uptake has now been defined, along with the pivotal role of the phytochrome-B signalling cascades that mediate this effect.

    • Hatem Rouached
    Nature Plants 4, 983-984
  • News and Views |

    Cellular components can be digested in the vacuole by autophagy, a critical process for homeostasis and stress tolerance. Functions of this recycling pathway in maize have now been defined, including lipid degradation, control of secondary metabolism and remodelling of the proteome.

    • Diane C. Bassham
    Nature Plants 4, 985-986
  • News and Views |

    Leaf senescence plays a crucial role in nutrient recovery in late-stage plant development and requires vast transcriptional reprogramming by transcription factors such as ORESARA1 (ORE1). A proteolytic mechanism is now found to control ORE1 degradation, and thus senescence, during nitrogen starvation.

    • Salma Balazadeh
    •  & Bernd Mueller-Roeber
    Nature Plants 4, 863-864
  • News and Views |

    Rag GTPases facilitate mTORC1 activation by recruiting it to Rheb at the lysosome when amino acids are abundant. A study now shows that the amino acid-induced change in the GTP/GDP-binding state of the Rag heterodimer paradoxically increases its dynamic release from the Ragulator at the lysosome and may limit mTORC1 activation.

    • Aaron M. Hosios
    •  & Brendan D. Manning
    Nature Cell Biology 20, 996-997
  • Research Highlights |

    PI3K inhibition in solid cancers driven by PI3K catalytic subunit-α has shown limited clinical benefit. This might be due to activation of a glucose–insulin feedback loop, which can be interrupted by dietary or pharmaceutical approaches, thereby improving therapy outcome.

    • Ulrike Harjes
    Nature Reviews Cancer 18, 530-531