Nutrient signalling

Nutrient signalling encompasses various cell signalling pathways that are regulated by nutrient availability. Changing nutrient levels activates signalling cascades that modulate fundamental cellular processes including metabolism, proliferation, secretion and autophagy.

Latest Research and Reviews

News and Comment

  • News and Views |

    Light is a critical environmental factor that influences nutrient uptake in roots and the subsequent use of nutrients, which is necessary to sustain plant growth. The positive effect of red light on phosphorus uptake has now been defined, along with the pivotal role of the phytochrome-B signalling cascades that mediate this effect.

    • Hatem Rouached
    Nature Plants 4, 983-984
  • News and Views |

    Cellular components can be digested in the vacuole by autophagy, a critical process for homeostasis and stress tolerance. Functions of this recycling pathway in maize have now been defined, including lipid degradation, control of secondary metabolism and remodelling of the proteome.

    • Diane C. Bassham
    Nature Plants 4, 985-986
  • News and Views |

    Leaf senescence plays a crucial role in nutrient recovery in late-stage plant development and requires vast transcriptional reprogramming by transcription factors such as ORESARA1 (ORE1). A proteolytic mechanism is now found to control ORE1 degradation, and thus senescence, during nitrogen starvation.

    • Salma Balazadeh
    •  & Bernd Mueller-Roeber
    Nature Plants 4, 863-864
  • News and Views |

    Rag GTPases facilitate mTORC1 activation by recruiting it to Rheb at the lysosome when amino acids are abundant. A study now shows that the amino acid-induced change in the GTP/GDP-binding state of the Rag heterodimer paradoxically increases its dynamic release from the Ragulator at the lysosome and may limit mTORC1 activation.

    • Aaron M. Hosios
    •  & Brendan D. Manning
    Nature Cell Biology 20, 996-997
  • Research Highlights |

    PI3K inhibition in solid cancers driven by PI3K catalytic subunit-α has shown limited clinical benefit. This might be due to activation of a glucose–insulin feedback loop, which can be interrupted by dietary or pharmaceutical approaches, thereby improving therapy outcome.

    • Ulrike Harjes
    Nature Reviews Cancer 18, 530-531