Nutrient signalling

Definition

Nutrient signalling encompasses various cell signalling pathways that are regulated by nutrient availability. Changing nutrient levels activates signalling cascades that modulate fundamental cellular processes including metabolism, proliferation, secretion and autophagy.

Latest Research and Reviews

  • Research | | open

    mTORC1 activity is controlled through Rag GTPases, which are anchored to the lysosome through the Ragulator. Here, the authors give molecular insights into Ragulator-Rag GTPase assembly and present the crystal structures of the Ragulator alone and in complex with the RagA-C roadblock domains.

    • Ryo Yonehara
    • , Shigeyuki Nada
    • , Tomokazu Nakai
    • , Masahiro Nakai
    • , Ayaka Kitamura
    • , Akira Ogawa
    • , Hirokazu Nakatsumi
    • , Keiichi I. Nakayama
    • , Songling Li
    • , Daron M. Standley
    • , Eiki Yamashita
    • , Atsushi Nakagawa
    •  & Masato Okada
  • Research |

    O’Farrell et al. show that class III PI3K regulates epithelial integrity through endosomal LKB1. Class III PI3K inactivation dysregulates LKB1 to alter cell polarity, and the PtdIns3P effector WDFY2 regulates LKB1.

    • Fergal O’Farrell
    • , Viola Hélène Lobert
    • , Marte Sneeggen
    • , Ashish Jain
    • , Nadja Sandra Katheder
    • , Eva Maria Wenzel
    • , Sebastian Wolfgang Schultz
    • , Kia Wee Tan
    • , Andreas Brech
    • , Harald Stenmark
    •  & Tor Erik Rusten
  • Research | | open

    Yeast and cancer cells both favor sugar fermentation in aerobic conditions. Here the authors describe a conserved mechanism from yeast to mammals where the glycolysis intermediate fructose-1,6-bisphosphate binds Cdc25/Sos1 and couples increased glycolytic flux to increased Ras proto-oncoprotein activity.

    • Ken Peeters
    • , Frederik Van Leemputte
    • , Baptiste Fischer
    • , Beatriz M. Bonini
    • , Hector Quezada
    • , Maksym Tsytlonok
    • , Dorien Haesen
    • , Ward Vanthienen
    • , Nuno Bernardes
    • , Carmen Bravo Gonzalez-Blas
    • , Veerle Janssens
    • , Peter Tompa
    • , Wim Versées
    •  & Johan M. Thevelein
  • Reviews |

    AMP-activated protein kinase (AMPK) senses cellular energy levels and phosphorylates a variety of cellular substrates to inhibit or stimulate anabolic and catabolic processes, adjusting metabolism to energy needs. Recent studies have uncovered a crucial role of AMPK in the regulation of mitochondrial dynamics and mitophagy, further expanding its role in the control of cellular metabolism.

    • Sébastien Herzig
    •  & Reuben J. Shaw

News and Comment