Numerical simulations articles within Nature Communications

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• Article
  11 July 2023 | Open Access

  The role of vaccination and public awareness in forecasts of Mpox incidence in the United Kingdom

  An outbreak of Mpox in the UK began in May 2022 and peaked in July. In this modelling study, the authors show that the decline in cases was likely due to behavioural changes among high-risk populations, whilst vaccination could prevent a rebound.

  • Samuel P. C. Brand
  • , Massimo Cavallaro
  •  & Matt J. Keeling

• Article
  04 October 2019 | Open Access

  Mouse embryo geometry drives formation of robust signaling gradients through receptor localization

  How receptor localization affects morphogen gradient formation during embryonic development is unclear. Here, the authors study the relationship between the BMP gradient, receptor localization, and compartmentalized geometry in the early mouse embryo, using experimental data and computational simulation.

  • Zhechun Zhang
  • , Steven Zwick
  •  & Sharad Ramanathan

• Article | 13 March 2012

  Sensitivity control through attenuation of signal transfer efficiency by negative regulation of cellular signalling

  How the sensitivity of biological and pharmacological signalling responses is controlled is poorly understood. Here, computational analyses and cellular experiments show that the sensitivity of a simple biochemical reaction to activators and inhibitors is controlled by negative regulation of cellular signalling.

  • Yu Toyoshima
  • , Hiroaki Kakuda
  •  & Shinya Kuroda