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| Open AccessNonlinear delay differential equations and their application to modeling biological network motifs
Network motif models focus on small sub-networks in biological systems to quantitatively describe overall behavior but they often overlook time delays. Here, the authors systematically examine the most common network motifs via delay differential equations (DDE), often leading to more concise descriptions.
- David S. Glass
- , Xiaofan Jin
- & Ingmar H. Riedel-Kruse
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Article
| Open AccessGene regulatory network inference from sparsely sampled noisy data
Gene regulatory network inference is a topical problem in systems biology. Here, the authors presents BINGO, a powerful method for network inference from time series data.
- Atte Aalto
- , Lauri Viitasaari
- & Jorge Gonçalves
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Article
| Open AccessA theoretical framework for controlling complex microbial communities
Controlling microbial communities could help restore ecosystems and maintain healthy microbiota. Here, the authors introduce the notion of structural accessibility and develop a framework to identify minimal sets of driver species, manipulation of which could allow control of a microbial community.
- Marco Tulio Angulo
- , Claude H. Moog
- & Yang-Yu Liu
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Article
| Open AccessOn chaotic dynamics in transcription factors and the associated effects in differential gene regulation
It is becoming clear that the dynamics of transcription factors may be important for gene regulation. Here, the authors study the implications of oscillatory and chaotic dynamics of NF-κB and demonstrate that it allows a degree of control of gene expression and can generate phenotypic heterogeneity.
- Mathias L. Heltberg
- , Sandeep Krishna
- & Mogens H. Jensen
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Article
| Open AccessFronts and waves of actin polymerization in a bistability-based mechanism of circular dorsal ruffles
Circular dorsal ruffles (CDRs) are important for the vesicular uptake of extracellular matter, but the basis of their wave dynamics is not understood. Here, the authors propose and experimentally test a bistable reaction-diffusion system, which they show accounts for the typical CDR expansion and shrinkage and for aberrant formation of pinned waves and spirals.
- Erik Bernitt
- , Hans-Günther Döbereiner
- & Arik Yochelis
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Article
| Open AccessExploratory adaptation in large random networks
Recent works suggest that cellular networks may respond to novel challenges on the time-scale of cellular lifetimes through large-scale perturbation of gene expression and convergence to a new state. Here, the authors demonstrate the theoretical feasibility of exploratory adaptation in cellular networks by showing that convergence to new states depends on known features of these networks.
- Hallel I. Schreier
- , Yoav Soen
- & Naama Brenner
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Realistic control of network dynamics
Nonlinearity is a hallmark of complex networks, but has generally been regarded as an obstacle to controlling their behaviour. Here Cornelius et al.show how nonlinear dynamics can be harnessed to control a network and drive it to desired states.
- Sean P. Cornelius
- , William L. Kath
- & Adilson E. Motter