NK cells

NK (natural killer) cells are a population of lymphocytes with both innate and adaptive immune features. They produce cytotoxic molecules and can eliminate infected cells or cancer cells.

Latest Research and Reviews

  • Research | | open

    Senescent cells increase with ageing and may cause inflammatory conditions, but how this accumulation is mediated is still unclear. Here the authors show that senescent cells express HLA-E to suppress NKG2A-mediated natural killer and CD8 T cell activation to avoid targeted elimination, while blocking NKG2A helps promote immunity against senescent cells.

    • Branca I. Pereira
    • , Oliver P. Devine
    • , Milica Vukmanovic-Stejic
    • , Emma S. Chambers
    • , Priya Subramanian
    • , Neil Patel
    • , Alex Virasami
    • , Neil J. Sebire
    • , Veronica Kinsler
    • , Alexis Valdovinos
    • , Claude Jourdan LeSaux
    • , João F. Passos
    • , Antony Antoniou
    • , Malcom H. A. Rustin
    • , Judith Campisi
    •  & Arne N. Akbar
  • Research | | open

    Despite the current human CD4 memory T cell stratification by CD45RA/CCR7, functional heterogeneities still exist within the respective subsets. Here the authors show that several surface markers, including KLRB1, KLRG1, GPR56 and KLRF1, help to further refine the subsetting of human CD4 memory T cells and provide insights for their differentiation.

    • Kim-Long Truong
    • , Stephan Schlickeiser
    • , Katrin Vogt
    • , David Boës
    • , Katarina Stanko
    • , Christine Appelt
    • , Mathias Streitz
    • , Gerald Grütz
    • , Nadja Stobutzki
    • , Christian Meisel
    • , Christina Iwert
    • , Stefan Tomiuk
    • , Julia K. Polansky
    • , Andreas Pascher
    • , Nina Babel
    • , Ulrik Stervbo
    • , Igor Sauer
    • , Undine Gerlach
    •  & Birgit Sawitzki
  • Research |

    Natural killer cells have important roles in virus and anti-cancer responses. Glimcher and colleagues demonstrate that a natural killer cell-intrinsic endoplasmic reticulum stress pathway is essential for their proper function.

    • Han Dong
    • , Nicholas M. Adams
    • , Yichi Xu
    • , Jin Cao
    • , David S. J. Allan
    • , James R. Carlyle
    • , Xi Chen
    • , Joseph C. Sun
    •  & Laurie H. Glimcher
    Nature Immunology 20, 865-878
  • Research | | open

    Immune cells may become less responsive, or ‘exhausted’, upon chronic viral infection, but the underlying mechanism and crosstalk are still unclear. Here the authors show that, upon chronic hepatitis C virus (HCV) infection, natural killer cell exhaustion is induced by NKG2A signalling to instruct downstream exhaustion of CD8+ T cells and HCV persistence.

    • Chao Zhang
    • , Xiao-mei Wang
    • , Shu-ran Li
    • , Trix Twelkmeyer
    • , Wei-hong Wang
    • , Sheng-yuan Zhang
    • , Shu-feng Wang
    • , Ji-zheng Chen
    • , Xia Jin
    • , Yu-zhang Wu
    • , Xin-wen Chen
    • , Sheng-dian Wang
    • , Jun-qi Niu
    • , Hai-rong Chen
    •  & Hong Tang
  • Research | | open

    The phosphatase Shp-2 was implicated in NK cell education due to its reported association with inhibitory receptors, but its function in this context is unclear. Here the authors show that Shp-2 is not required for NK cell function, but is necessary for IL-15-induced metabolic burst and expansion.

    • Charlène Niogret
    • , S. M. Shahjahan Miah
    • , Giorgia Rota
    • , Nicolas P. Fonta
    • , Haiping Wang
    • , Werner Held
    • , Walter Birchmeier
    • , Veronica Sexl
    • , Wentian Yang
    • , Eric Vivier
    • , Ping-Chih Ho
    • , Laurent Brossay
    •  & Greta Guarda

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