NF-kappaB

Nuclear factor-kappaB (NF-κB) is a family of transcription factors that regulate diverse processes in immune cells, including cell survival and proliferation, cell differentiation and cytokine production.

Latest Research and Reviews

  • Research | | open

    Ubiquitination may control protein stability or function. Here the authors show that an ubiquitination enzyme, Hectd3, ubiquitinates Stat3 and Malt1 to modulate their function but not degradation in T cells, and thereby promoting the differentiation of pathogenic Th17 cells and susceptibility to a mouse model of multiple sclerosis.

    • Jonathan J. Cho
    • , Zhiwei Xu
    • , Upasana Parthasarathy
    • , Theodore T. Drashansky
    • , Eric Y. Helm
    • , Ashley N. Zuniga
    • , Kyle J. Lorentsen
    • , Samira Mansouri
    • , Joshua Y. Cho
    • , Mariola J. Edelmann
    • , Duc M. Duong
    • , Torben Gehring
    • , Thomas Seeholzer
    • , Daniel Krappmann
    • , Mohammad N. Uddin
    • , Danielle Califano
    • , Rejean L. Wang
    • , Lei Jin
    • , Hongmin Li
    • , Dongwen Lv
    • , Daohong Zhou
    • , Liang Zhou
    •  & Dorina Avram
  • Research | | open

    Microfold cells (M-cell) are specialized cells of the intestine that sample luminal microbiota and dietary antigens. Here the authors show that epithelial non-canonical NFκB signalling, as induced by NIK, is important for M-cells maintenance, yet constitutive NIK activation is associated with gut inflammation and inflammatory bowel disease.

    • Sadeesh K. Ramakrishnan
    • , Huabing Zhang
    • , Xiaoya Ma
    • , Inkyung Jung
    • , Andrew J. Schwartz
    • , Daniel Triner
    • , Samantha N. Devenport
    • , Nupur K. Das
    • , Xiang Xue
    • , Melody Y. Zeng
    • , Yinling Hu
    • , Richard M. Mortensen
    • , Joel K Greenson
    • , Marilia Cascalho
    • , Christiane E. Wobus
    • , Justin A. Colacino
    • , Gabriel Nunez
    • , Liangyou Rui
    •  & Yatrik M. Shah
  • Research | | open

    Regulatory T (Treg) cells are important for maintaining immune homeostasis by suppressing immune cell activation, but how the Treg cell pool is maintained is still unclear. Here the authors show that a kinase, Lkb1, operates in dendritic cells (DC) to inhibit Treg cell expansion and immunosuppression via mechanisms involving NF-kB/OX40L signalling.

    • Song Chen
    • , Lijun Fang
    • , Wei Guo
    • , Yushan Zhou
    • , Gang Yu
    • , Wenwen Li
    • , Kui Dong
    • , Jingru Liu
    • , Yuechen Luo
    • , Bing Wang
    • , Zhonglong Li
    • , Chunxiao Zhao
    • , Zhina Sun
    • , Yue Shen
    • , Qibing Leng
    • , Dongming Zhou
    • , Zhongchao Han
    • , Huifang Huang
    • , He Ren
    • , Guogang Xu
    •  & Xiaoming Feng
  • Research | | open

    Nuclear factor-kappa B (NF-κB) signaling is regulated by ubiquitin to maintain immune homeostasis. Here the authors show that a peptidylprolyl isomerase, CYPJ, blocks TAB2/3 or LUBAC ubiquitin chain sensing and suppress NF-κB activation, with CYPJ-deficiency leading to susceptibility to inflammatory stimuli.

    • Chunjie Sheng
    • , Chen Yao
    • , Ziyang Wang
    • , Hongyuan Chen
    • , Yu Zhao
    • , Dazhi Xu
    • , Haojie Huang
    • , Wenlin Huang
    •  & Shuai Chen

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