Neutrophils

Neutrophils are a type of innate immune cell that contains distinctive cytoplasmic granules and a nucleus that is divided into three segments. They are the most abundant immune cell type in the blood. Neutrophils are rapidly recruited to infected tissues and can engulf bacteria directly or produce toxic antimicrobial mediators.

Latest Research and Reviews

  • Research |

    Bone marrow-derived cells can rapidly enter the systemic circulation, but how this is achieved is unclear. Grüneboom et al. identify tiny capillaries, termed trans-cortical vessels (TCVs), that connect the bone marrow cavity to the systemic vasculature, and show that the majority of blood in long bones passes through TCVs.

    • Anika Grüneboom
    • , Ibrahim Hawwari
    • , Daniela Weidner
    • , Stephan Culemann
    • , Sylvia Müller
    • , Sophie Henneberg
    • , Alexandra Brenzel
    • , Simon Merz
    • , Lea Bornemann
    • , Kristina Zec
    • , Manuela Wuelling
    • , Lasse Kling
    • , Mike Hasenberg
    • , Sylvia Voortmann
    • , Stefanie Lang
    • , Wolfgang Baum
    • , Alexandra Ohs
    • , Oliver Kraff
    • , Harald H. Quick
    • , Marcus Jäger
    • , Stefan Landgraeber
    • , Marcel Dudda
    • , Renzo Danuser
    • , Jens V. Stein
    • , Manfred Rohde
    • , Kolja Gelse
    • , Annette I. Garbe
    • , Alexandra Adamczyk
    • , Astrid M. Westendorf
    • , Daniel Hoffmann
    • , Silke Christiansen
    • , Daniel Robert Engel
    • , Andrea Vortkamp
    • , Gerhard Krönke
    • , Martin Herrmann
    • , Thomas Kamradt
    • , Georg Schett
    • , Anja Hasenberg
    •  & Matthias Gunzer
    Nature Metabolism 1, 236-250
  • Research | | open

    • Kelly L. Singel
    • , Kassondra S. Grzankowski
    • , A. N. M. Nazmul H. Khan
    • , Melissa J. Grimm
    • , Anthony C. D’Auria
    • , Kayla Morrell
    • , Kevin H. Eng
    • , Bonnie Hylander
    • , Paul C. Mayor
    • , Tiffany R. Emmons
    • , Nikolett Lénárt
    • , Rebeka Fekete
    • , Zsuzsanna Környei
    • , Uma Muthukrishnan
    • , Jonathan D. Gilthorpe
    • , Constantin F. Urban
    • , Kiyoshi Itagaki
    • , Carl J. Hauser
    • , Cynthia Leifer
    • , Kirsten B. Moysich
    • , Kunle Odunsi
    • , Ádám Dénes
    •  & Brahm H. Segal
  • Research | | open

    Neutrophils normally fulfil their metabolic demands by glycolysis and have limited mitochondrial activity. Here the authors show that tumours promote neutrophils adapted to oxidative mitochondria metabolism that function in the glucose-restrained tumour microenvironment to promote tumour growth by maintaining local immune suppression.

    • Christopher M. Rice
    • , Luke C. Davies
    • , Jeff J. Subleski
    • , Nunziata Maio
    • , Marieli Gonzalez-Cotto
    • , Caroline Andrews
    • , Nimit L. Patel
    • , Erika M. Palmieri
    • , Jonathan M. Weiss
    • , Jung-Min Lee
    • , Christina M. Annunziata
    • , Tracey A. Rouault
    • , Scott K. Durum
    •  & Daniel W. McVicar
  • Research | | open

    Neutrophil extracellular traps (NETs) are known to promote metastasis in mouse models. Here the authors show plasma redox imbalance caused by albumin oxidation to induce inflammation-independent NETosis and lung metastasis, and albumin oxidation and reduced plasma free thiol to be associated with lung metastasis in a cohort of head and neck cancer patients.

    • Minoru Inoue
    • , Ryota Nakashima
    • , Masahiro Enomoto
    • , Yuhki Koike
    • , Xiao Zhao
    • , Kenneth Yip
    • , Shao Hui Huang
    • , John N. Waldron
    • , Mitsuhiko Ikura
    • , Fei-Fei Liu
    •  & Scott V. Bratman
  • Research | | open

    Deposited immune complexes (IC) promote neutrophil recruitment, but the fine tuning of this process is still unclear. Here the authors show that the cis interaction of the IC receptor, FcγRIIA and CD18 integrin, Mac-1, on the neutrophil surface modulates neutrophil adhesion, with FcγRIIA sialylation specifically implicated in this interaction.

    • Gurpanna Saggu
    • , Koshu Okubo
    • , Yunfeng Chen
    • , Ravi Vattepu
    • , Naotake Tsuboi
    • , Florencia Rosetti
    • , Xavier Cullere
    • , Nathaniel Washburn
    • , Suhail Tahir
    • , Aaron M. Rosado
    • , Steven M. Holland
    • , Robert M. Anthony
    • , Mehmet Sen
    • , Cheng Zhu
    •  & Tanya N. Mayadas

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