Neurotransmitters

Neurotransmitters are biological molecules that are secreted by neurons and that alter the behaviour of their target neurons or effector cells.

Latest Research and Reviews

  • Research |

    The activation mechanism of metabotropic glutamate receptor subtype 5, a member of the family C G-protein-coupled receptors, is characterized by a combination of cryo-electron microscopy, crystallography and signalling studies.

    • Antoine Koehl
    • , Hongli Hu
    • , Dan Feng
    • , Bingfa Sun
    • , Yan Zhang
    • , Michael J. Robertson
    • , Matthew Chu
    • , Tong Sun Kobilka
    • , Toon Laermans
    • , Jan Steyaert
    • , Jeffrey Tarrasch
    • , Somnath Dutta
    • , Rasmus Fonseca
    • , William I. Weis
    • , Jesper M. Mathiesen
    • , Georgios Skiniotis
    •  & Brian K. Kobilka
    Nature 566, 79-84
  • Research | | open

    It has proven difficult to measure the release of neurotransmitters, such as dopamine, in the human brain. Here, the authors introduce and validate a new method that infers dopamine release based on minute-by-minute fluctuations of the positron emission tomography (PET) radioligand [11C]raclopride.

    • Rachel N. Lippert
    • , Anna Lena Cremer
    • , Sharmili Edwin Thanarajah
    • , Clio Korn
    • , Thomas Jahans-Price
    • , Lauren M. Burgeno
    • , Marc Tittgemeyer
    • , Jens C. Brüning
    • , Mark E. Walton
    •  & Heiko Backes
  • Research |

    A high-resolution cryo-electron microscopy structure is reported for the full-length human α1β3γ2L GABAA receptor, functionally reconstituted in lipid nanodiscs.

    • Duncan Laverty
    • , Rooma Desai
    • , Tomasz Uchański
    • , Simonas Masiulis
    • , Wojciech J. Stec
    • , Tomas Malinauskas
    • , Jasenko Zivanov
    • , Els Pardon
    • , Jan Steyaert
    • , Keith W. Miller
    •  & A. Radu Aricescu
    Nature 565, 516-520
  • Research | | open

    Excitatory glycine GluN1/GluN3A receptors are atypical NMDARs that have been difficult to study. Here the authors identify new properties of these receptors, including potentiation by the GluN1 antagonist CGP-78608 that allows detection of functional GluN1/GluN3A receptors in the juvenile brain.

    • Teddy Grand
    • , Sarah Abi Gerges
    • , Mélissa David
    • , Marco A. Diana
    •  & Pierre Paoletti
  • Research | | open

    The precise relationship between neurobehavioural effects and neurotransmitter effects of psychiatric drugs are not always understood. Here the authors develop a database documenting the neurotransmitter response in rats to 258 different neuropsychiatric drugs, and conclude that this neurotransmitter response does not, in general, reflect the current categorisation of those drugs.

    • Hamid R. Noori
    • , Lewis H. Mervin
    • , Vahid Bokharaie
    • , Özlem Durmus
    • , Lisamon Egenrieder
    • , Stefan Fritze
    • , Britta Gruhlke
    • , Giulia Reinhardt
    • , Hans-Hendrik Schabel
    • , Sabine Staudenmaier
    • , Nikos K. Logothetis
    • , Andreas Bender
    •  & Rainer Spanagel

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