Neurosurgery is a surgical procedure that uses invasive techniques to diagnose, investigate and/or treat a neurological disorder, disease or injury. For example, to remove a brain tumour or insert a deep brain stimulation device.

Latest Research and Reviews

  • Reviews |

    Deep brain stimulation is used to treat a variety of neurological conditions, including Parkinson disease, dystonia and intractable pain, but the mechanisms underlying its therapeutic effects remain unclear. Drawing on clinical and experimental data, the authors examine hypotheses that have been proposed to explain the effects of DBS, and present the case for a change in terminology to 'deep brain neuromodulation'.

    • Keyoumars Ashkan
    • , Priya Rogers
    • , Hagai Bergman
    •  & Ismail Ughratdar
  • Reviews |

    In the past few years, paradigms for the treatment of low-grade glioma have shifted, owing to new diagnostic criteria and new clinical trial evidence. Here, Jan Buckner and colleagues discuss how molecular markers are challenging previous assumptions about low-grade glioma, and examine how new data will affect diagnostic testing, surgery, chemotherapy and radiation therapy for individuals with these tumours.

    • Jan Buckner
    • , Caterina Giannini
    • , Jeanette Eckel-Passow
    • , Daniel Lachance
    • , Ian Parney
    • , Nadia Laack
    •  & Robert Jenkins
  • Reviews |

    Childhood-onset craniopharyngioma is a rare embryonic tumour of low-grade malignancy that has traditionally been treated by radical resection. Here, Müller and colleagues review recent advances in the molecular pathogenesis of the disease and treatment strategies that could lead to novel targeted therapies and more-limited surgeries.

    • Hermann L. Müller
    • , Thomas E. Merchant
    • , Stephanie Puget
    •  & Juan-Pedro Martinez-Barbera
  • Reviews |

    Gilles de la Tourette syndrome (GTS) is a childhood-onset neurodevelopmental disorder that is characterized by several motor tics and at least one phonic tic. In this Primer, Robertson et al. describe the epidemiology, pathophysiology, diagnosis and management of GTS in detail.

    • Mary M. Robertson
    • , Valsamma Eapen
    • , Harvey S. Singer
    • , Davide Martino
    • , Jeremiah M. Scharf
    • , Peristera Paschou
    • , Veit Roessner
    • , Douglas W. Woods
    • , Marwan Hariz
    • , Carol A. Mathews
    • , Rudi Črnčec
    •  & James F. Leckman
  • Reviews |

    Access to the brain remains a challenge in surgical and drug treatment of neurological disorders, but therapeutic use of ultrasound offers a realistic alternative to overcome the challenges. In this Review, the authors provide an overview of how ultrasound can be used for neurosurgery to ablate pathological tissue, for drug delivery by opening the blood–brain barrier, and for neuromodulation.

    • Gerhard Leinenga
    • , Christian Langton
    • , Rebecca Nisbet
    •  & Jürgen Götz

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