Neuroscience

Definition

Neuroscience is a multidisciplinary science that is concerned with the study of the structure and function of the nervous system. It encompasses the evolution, development, cellular and molecular biology, physiology, anatomy and pharmacology of the nervous system, as well as computational, behavioural and cognitive neuroscience.

Featured

Latest Research and Reviews

  • Reviews |

    This Review describes the key insights into urologic chronic pelvic pain syndrome (UCPPS) from the first phase of Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network studies and highlights their implications for understanding the pathophysiological basis and clinical management of UCPPS.

    • J. Quentin Clemens
    • , Chris Mullins
    • , A. Lenore Ackerman
    • , Tamara Bavendam
    • , Adrie van Bokhoven
    • , Benjamin M. Ellingson
    • , Steven E. Harte
    • , Jason J. Kutch
    • , H. Henry Lai
    • , Katherine T. Martucci
    • , Robert Moldwin
    • , Bruce D. Naliboff
    • , Michel A. Pontari
    • , Siobhan Sutcliffe
    •  & J. Richard Landis
  • Research |

    Controlled tissue fixation with polyepoxides protects protein fluorescence, antigenicity, nucleic acids and tissue architecture.

    • Young-Gyun Park
    • , Chang Ho Sohn
    • , Ritchie Chen
    • , Margaret McCue
    • , Dae Hee Yun
    • , Gabrielle T Drummond
    • , Taeyun Ku
    • , Nicholas B Evans
    • , Hayeon Caitlyn Oak
    • , Wendy Trieu
    • , Heejin Choi
    • , Xin Jin
    • , Varoth Lilascharoen
    • , Ji Wang
    • , Matthias C Truttmann
    • , Helena W Qi
    • , Hidde L Ploegh
    • , Todd R Golub
    • , Shih-Chi Chen
    • , Matthew P Frosch
    • , Heather J Kulik
    • , Byung Kook Lim
    •  & Kwanghun Chung
  • Research |

    Using a newly developed biochemical method for aggregated protein extraction, Laferrière and colleagues uncover different neurotoxic types of pathologic TDP-43 assemblies in the brains of subjects with distinct subtypes of frontotemporal dementia.

    • Florent Laferrière
    • , Zuzanna Maniecka
    • , Manuela Pérez-Berlanga
    • , Marian Hruska-Plochan
    • , Larissa Gilhespy
    • , Eva-Maria Hock
    • , Ulrich Wagner
    • , Tariq Afroz
    • , Paul J. Boersema
    • , Gery Barmettler
    • , Sandrine C. Foti
    • , Yasmine T. Asi
    • , Adrian M. Isaacs
    • , Ashraf Al-Amoudi
    • , Amanda Lewis
    • , Henning Stahlberg
    • , John Ravits
    • , Francesca De Giorgi
    • , François Ichas
    • , Erwan Bezard
    • , Paola Picotti
    • , Tammaryn Lashley
    •  & Magdalini Polymenidou
  • Research |

    A photosensitizer-tagged derivative of the interleukin-31 ligand that mediates the photoablation of itch-sensing skin neurons expressing the corresponding interleukin receptor reverses scratching behaviour of mice with atopic dermatitis.

    • Linda Nocchi
    • , Nainika Roy
    • , Mariangela D’Attilia
    • , Rahul Dhandapani
    • , Mariano Maffei
    • , Andrei Traista
    • , Laura Castaldi
    • , Emerald Perlas
    • , Cora Hallie Chadick
    •  & Paul A. Heppenstall
  • Research |

    Polanía et al. show that, similarly to sensory signals, subjective preferences guiding choice are represented by the brain in a manner that accounts for regularities of the environment, thereby optimizing use of limited neural processing resources.

    • Rafael Polanía
    • , Michael Woodford
    •  & Christian C. Ruff
    Nature Neuroscience 22, 134–142
  • Research |

    RNA antisense oligonucleotide therapy to restore normal splicing of a ciliopathy gene shows promising safety and efficacy results in a clinical trial to treat a form of childhood blindness.

    • Artur V. Cideciyan
    • , Samuel G. Jacobson
    • , Arlene V. Drack
    • , Allen C. Ho
    • , Jason Charng
    • , Alexandra V. Garafalo
    • , Alejandro J. Roman
    • , Alexander Sumaroka
    • , Ian C. Han
    • , Maria D. Hochstedler
    • , Wanda L. Pfeifer
    • , Elliott H. Sohn
    • , Magali Taiel
    • , Michael R. Schwartz
    • , Patricia Biasutto
    • , Wilma de Wit
    • , Michael E. Cheetham
    • , Peter Adamson
    • , David M. Rodman
    • , Gerard Platenburg
    • , Maria D. Tome
    • , Irina Balikova
    • , Fanny Nerinckx
    • , Julie De Zaeytijd
    • , Caroline Van Cauwenbergh
    • , Bart P. Leroy
    •  & Stephen R. Russell

News and Comment

  • News and Views |

    TDP-43 forms cytoplasmic aggregates in degenerating neurons of frontotemporal dementia (FTD) patients. Laferrière et al. now establish that TDP-43 assemblies from distinct FTD subtypes have different structures, neurotoxicities, and seeding activities, which correlate with FTD severity. Thus, distinct pathological TDP-43 assemblies akin to prion strains might underpin distinct FTD subtypes.

    • Edward M. Barbieri
    •  & James Shorter
  • News and Views |

    In 2010, Johnson and Kenny provided conclusive evidence that extended access to a Western-style diet promotes addictive-like behavior in rats by downregulating D2 receptors while promoting obesity. This focused attention on the parallels between drug addiction and overeating and fueled a decade of food addiction research.

    • Alexandra G. DiFeliceantonio
    •  & Dana M. Small
  • News and Views |

    The locus coeruleus is known to be an essential source of neuromodulation that influences sensory processing, including the enhancement of feature selectivity associated with attentional focus. A new study shows that the primary sensory thalamus encompasses one circuit that underlies this enhancement.

    • Tingting Zhou
    •  & Michael M Halassa
  • Research Highlights |

    Repetitive sensory input induces long-term potentiation of pyramidal cell synapses in mouse somatosensory cortex by activation of higher-order thalamic projections and disinhibition of local interneurons.

    • Sian Lewis