Neuroscience

Definition

Neuroscience is a multidisciplinary science that is concerned with the study of the structure and function of the nervous system. It encompasses the evolution, development, cellular and molecular biology, physiology, anatomy and pharmacology of the nervous system, as well as computational, behavioural and cognitive neuroscience.

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Latest Research and Reviews

  • Protocols |

    The levels of monoamines and their cofactors in cerebrospinal fluid are strong indicators for dopamine and serotonin biosynthesis and turnover. This protocol describes a set of HPLC-based approaches for the quantitative detection of these molecules.

    • Marta Batllori
    • , Marta Molero-Luis
    • , Aida Ormazabal
    • , Mercedes Casado
    • , Cristina Sierra
    • , Angels García-Cazorla
    • , Manju Kurian
    • , Simon Pope
    • , Simon J Heales
    •  & Rafael Artuch
    Nature Protocols 12, 2359–2375
  • Research |

    Interactions with male and female intruders activated overlapping neuronal populations in the ventromedial hypothalamus of inexperienced adult male mice, and these ensembles gradually separated as the mice acquired social and sexual experience with conspecifics.

    • Ryan Remedios
    • , Ann Kennedy
    • , Moriel Zelikowsky
    • , Benjamin F. Grewe
    • , Mark J. Schnitzer
    •  & David J. Anderson
    Nature 550, 388–392
  • Research |

    Starting from zero knowledge and without human data, AlphaGo Zero was able to teach itself to play Go and to develop novel strategies that provide new insights into the oldest of games.

    • David Silver
    • , Julian Schrittwieser
    • , Karen Simonyan
    • , Ioannis Antonoglou
    • , Aja Huang
    • , Arthur Guez
    • , Thomas Hubert
    • , Lucas Baker
    • , Matthew Lai
    • , Adrian Bolton
    • , Yutian Chen
    • , Timothy Lillicrap
    • , Fan Hui
    • , Laurent Sifre
    • , George van den Driessche
    • , Thore Graepel
    •  & Demis Hassabis
    Nature 550, 354–359
  • Research | | open

    The mTOR pathway is a key regulator of normal brain development. Here, the authors identify de novo mutations in RHEB, an mTOR activator protein, in patients with intellectual disability associated with megalencephaly and find a role for RHEB in regulating neuronal soma size and migration in vitro and in vivo.

    • M. R. F. Reijnders
    • , M. Kousi
    • , G. M. van Woerden
    • , M. Klein
    • , J. Bralten
    • , G. M. S. Mancini
    • , T. van Essen
    • , M. Proietti-Onori
    • , E. E. J. Smeets
    • , M. van Gastel
    • , A. P. A. Stegmann
    • , S. J. C. Stevens
    • , S. H. Lelieveld
    • , C. Gilissen
    • , R. Pfundt
    • , P. L. Tan
    • , T. Kleefstra
    • , B. Franke
    • , Y. Elgersma
    • , N. Katsanis
    •  & H. G. Brunner
  • Research | | open

    VLDLR regulates cellular lipoprotein uptake and storage. Here, the authors show that VLDLR, expressed on adipose tissue macrophages, is upregulated in obesity and promotes adipose tissue inflammation by upregulating ceramide production and facilitating M1-like macrophage polarization.

    • Kyung Cheul Shin
    • , Injae Hwang
    • , Sung Sik Choe
    • , Jeu Park
    • , Yul Ji
    • , Jong In Kim
    • , Gha Young Lee
    • , Sung Hee Choi
    • , Jianhong Ching
    • , Jean-Paul Kovalik
    •  & Jae Bum Kim

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