Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer).
Neurogenic bladder is loss of bladder control caused by neurological disorders, such as neural tube defects, spinal cord diseases and injury. Symptoms include urinary incontinence, renal damage and recurrent urinary tract infection.
Lower urinary tract symptoms (LUTS) are common comorbidities in patients with Parkinson disease, or multiple system atrophy, and these can have considerable negative effects on patients' quality of life. In this Review, the authors describe the prevalence, diagnosis and management of LUTS in patients with PD or MSA, including the key differences in LUTS between patients with these disorders, which can, in some patients, enable a differential diagnosis.
Overactive bladder in children is a surprisingly common syndrome that can persist into adulthood. Evidence increasingly suggests that this syndrome can be explained by neurological changes or comorbidities. Here, the author describes the causes, symptoms and management of paediatric patients with overactive bladder.
Mirabegron has been shown to cause relaxation of the isolated mouse urethra, partly through blockade of α1A-adrenoceptors and α1D-adrenoceptors. However, although this effect might be an interesting pharmacological in vitro observation, it seems to have no relevance for the clinical use of mirabegron in the treatment of the overactive bladder.