Neuro–vascular interactions

Neuro–vascular interactions are the interactions between blood vessels in the brain and their adjacent neurons, and are regulated by complex interactions between endothelial cells, pericytes, fibroblasts, neurons and glia. They regulate blood flow and provide vital support for brain development and neuronal function. Defective neuro–vascular function is associated with a variety of neurological disorders.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    Certain cellular functions in artificially reperfused pig brains can be restored and maintained several hours after initial loss of cerebral blood flow.

    • Natasha Bray
  • News and Views |

    Excessive dietary salt can impair cerebral blood flow regulation, resulting in cognitive dysfunction in mice. A ‘gut–brain’ pathway is implicated that links expansion of TH17 lymphocytes in small intestine to elevated bloodstream interleukin-17, which impairs brain perfusion by decreasing nitric oxide production in brain vascular endothelium.

    • Mohammed A. Shaik
    •  & Elizabeth M. C. Hillman
    Nature Neuroscience 21, 154-155
  • News and Views |

    Capillary endothelial cells sense neuronal activity-evoked increases in extracellular K+ via KIR2.1 inwardly rectifying K+ channels. The ensuing hyperpolarization travels upstream along the vascular network, reaching arterioles and evoking vasodilation.

    • Jessica A Filosa
    Nature Neuroscience 20, 631-633
  • News and Views |

    During synaptic activation, the function of astrocyte endfeet depends on the vascular target: at the capillary, but not at the arteriole, a newly described P2X1R–phospholipase D2 pathway modulates prostaglandin E2 release and vessel dilation.

    • Ravi L Rungta
    •  & Serge Charpak
    Nature Neuroscience 19, 1539-1541