Neural tube defects

Definition

Neural tube defects result from a failure in closing of the neural tube during gastrulation, which causes congenital malformations of the spinal cord and brain. Open neural tube defects result in exposure of the brain and/or spinal cord at birth and include anencephaly, encephaloceles, hydranencephaly, iniencephaly, schizencephaly and spina bifida.

Latest Research and Reviews

  • Research | | open

    • E. Bourneuf
    • , P. Otz
    • , H. Pausch
    • , V. Jagannathan
    • , P. Michot
    • , C. Grohs
    • , G. Piton
    • , S. Ammermüller
    • , M.-C. Deloche
    • , S. Fritz
    • , H. Leclerc
    • , C. Péchoux
    • , A. Boukadiri
    • , C. Hozé
    • , R. Saintilan
    • , F. Créchet
    • , M. Mosca
    • , D. Segelke
    • , F. Guillaume
    • , S. Bouet
    • , A. Baur
    • , A. Vasilescu
    • , L. Genestout
    • , A. Thomas
    • , A. Allais-Bonnet
    • , D. Rocha
    • , M.-A. Colle
    • , C. Klopp
    • , D. Esquerré
    • , C. Wurmser
    • , K. Flisikowski
    • , H. Schwarzenbacher
    • , J. Burgstaller
    • , M. Brügmann
    • , E. Dietschi
    • , N. Rudolph
    • , M. Freick
    • , S. Barbey
    • , G. Fayolle
    • , C. Danchin-Burge
    • , L. Schibler
    • , B. Bed’Hom
    • , B. J. Hayes
    • , H. D. Daetwyler
    • , R. Fries
    • , D. Boichard
    • , D. Pin
    • , C. Drögemüller
    •  & A. Capitan
  • Reviews |

    Vitamin B12 (also known as cobalamin) is a B vitamin that has an important role in cellular metabolism, especially in DNA synthesis, methylation and mitochondrial metabolism. In this Primer, Green et al. describe the causes, consequences and management of vitamin B12 deficiency.

    • Ralph Green
    • , Lindsay H. Allen
    • , Anne-Lise Bjørke-Monsen
    • , Alex Brito
    • , Jean-Louis Guéant
    • , Joshua W. Miller
    • , Anne M. Molloy
    • , Ebba Nexo
    • , Sally Stabler
    • , Ban-Hock Toh
    • , Per Magne Ueland
    •  & Chittaranjan Yajnik
  • Reviews |

    Patients with spinal dysraphism can have a large variety of different urological manifestations, thus, effective clinical management of these patients can involve a range of different approaches. Here, authors describe the management of the full range of urological manifestations observed in patients with spinal dysraphism and the future challenges posed by the changing demographics of this patient population.

    • Paul W. Veenboer
    • , Laetitia M. O. de Kort
    • , Rafal J. Chrzan
    •  & Tom P. V. M. de Jong
  • Reviews |

    Spina bifida is a congenital disorder caused by failed closure of the neural tube, which leads to sensory, motor and cognitive dysfunction. Copp et al. discuss the prevalence and pathogenesis of spina bifida, as well as preventive actions, diagnostic methods and treatment options.

    • Andrew J. Copp
    • , N. Scott Adzick
    • , Lyn S. Chitty
    • , Jack M. Fletcher
    • , Grayson N. Holmbeck
    •  & Gary M. Shaw

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