Networks and systems biology

Networks and systems biology is the study of complex systems by a holistic approach where the 'omics approaches such as transcriptomics, glycomics and lipidomics find wide use. Networks and systems biology aims to understand the networks of interactions and effects of those interactions on a global scale, involving hundreds of different biological molecules simultaneously.

Latest Research and Reviews

  • Research | | open

    Alborz Mazloomian et al. use small molecule inhibitors to disrupt EIF4A3’s ATPase and helicase function which affects alternative splicing and nonsense mediated decay of transcripts. They define a genome-wide pattern of motifs of RNA-binding proteins associated with EIF4A3 and find that stress granules are downregulated upon EIF4A3 inhibition.

    • Alborz Mazloomian
    • , Shinsuke Araki
    • , Momoko Ohori
    • , Amal M. El-Naggar
    • , Damian Yap
    • , Ali Bashashati
    • , Shoichi Nakao
    • , Poul H. Sorensen
    • , Atsushi Nakanishi
    • , Sohrab Shah
    •  & Samuel Aparicio
  • Research | | open

    Gene expression profiles can classify breast cancer into five clinically relevant subtypes. Here, the authors perform an in-depth quantitative profiling of the proteome of 45 breast tumors, and show they can recapitulate the transcriptome-based classifications and identify many potentially antigenic tumour-specific peptides.

    • Henrik J. Johansson
    • , Fabio Socciarelli
    • , Nathaniel M. Vacanti
    • , Mads H. Haugen
    • , Yafeng Zhu
    • , Ioannis Siavelis
    • , Alejandro Fernandez-Woodbridge
    • , Miriam R. Aure
    • , Bengt Sennblad
    • , Mattias Vesterlund
    • , Rui M. Branca
    • , Lukas M. Orre
    • , Mikael Huss
    • , Erik Fredlund
    • , Elsa Beraki
    • , Øystein Garred
    • , Jorrit Boekel
    • , Torill Sauer
    • , Wei Zhao
    • , Silje Nord
    • , Elen K. Höglander
    • , Daniel C. Jans
    • , Hjalmar Brismar
    • , Tonje H. Haukaas
    • , Tone F. Bathen
    • , Ellen Schlichting
    • , Bjørn Naume
    • , Jürgen Geisler
    • , Solveig Hofvind
    • , Olav Engebråten
    • , Gry Aarum Geitvik
    • , Anita Langerød
    • , Rolf Kåresen
    • , Gunhild Mari Mælandsmo
    • , Therese Sørlie
    • , Helle Kristine Skjerven
    • , Daehoon Park
    • , Olaf-Johan Hartman-Johnsen
    • , Torben Luders
    • , Elin Borgen
    • , Vessela N. Kristensen
    • , Hege G. Russnes
    • , Ole Christian Lingjærde
    • , Gordon B. Mills
    • , Kristine K. Sahlberg
    • , Anne-Lise Børresen-Dale
    •  & Janne Lehtiö
  • Research | | open

    The mechanisms that accommodate variable external dependencies in evolution are not clear. Here, the authors show that switches between external and internal metabolic controls of carotenoid-producing networks in birds are linked to shifts in evolutionary rates, with internalization of control resulting in bursts of evolutionary diversification.

    • Alexander V. Badyaev
    • , Alexander B. Posner
    • , Erin S. Morrison
    •  & Dawn M. Higginson
  • Research | | open

    Combination therapy holds great promise, but discovery remains challenging. Here, the authors propose a method to identify efficacious drug combinations for specific diseases, and find that successful combinations tend to target separate neighbourhoods of the disease module in the human interactome.

    • Feixiong Cheng
    • , István A. Kovács
    •  & Albert-László Barabási

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