Nanotoxicology articles from across Nature Portfolio

A double-blind, randomized, controlled human exposure trial of highly purified and thin nanometre-sized graphene oxide nanosheets shows that acute inhalation of aerosolized nanoparticles is not associated with harmful effects in healthy humans.

Nanofibre lung injury has previously been linked to the leakage of reactive oxygen and nitrogen species in frustrated phagocytosis. Here the authors use a nanosensor to demonstrate, map and track the generation of reactive species during the frustrated phagocytosis of model glass nanofibres.

Carbon nanotubes are used in a growing number of applications, but recent European Union actions propose to ban them. This Perspective highlights gaps in knowledge regarding potential safety and environmental risks throughout the life cycle of carbon nanotubes and provides a framework to inform policy decisions.

An X-ray microscopy approach for 2D or 3D label-free visualization of the intracellular distribution of nanomedicines and the morphology of organelles in primary blood cells, macrophages, dendritic cells, monocytes and cancer cells.

A double-blind, randomized, controlled human exposure trial of highly purified and thin nanometre-sized graphene oxide nanosheets shows that acute inhalation of aerosolized nanoparticles is not associated with harmful effects in healthy humans.

Biodegradable polylactic acid (PLA) microplastics are shown to undergo enzymatic hydrolysis by lipases found in the human gut to generate PLA oligomers, which self-aggregate to form nanoplastic particles. The oligomers and their nanoparticles bioaccumulated in multiple organs of a mouse model and caused acute intestinal inflammation.

A common understanding of the key regulatory term “substance” is needed for the implementation of chemicals regulations for nanomaterials.

The challenge of assessing the scope and magnitude of risk from nanomaterials is urgent for society and ignoring risks could be detrimental for development. This challenge is bigger than the individual capacities on each side of the Atlantic, but effective cross-Atlantic collaboration can solve essential riddles about the use of nanomaterials.

Overcoming the challenges of plastic detection in plants has made it possible to transfer many of the lessons learned from plant–metal nanoparticle interactions to plastic nanoparticles.