Nanofabrication and nanopatterning articles from across Nature Portfolio

The authors propose a new method for two-photon microscopy that can produce large cranial windows covering both the cerebrum and cerebellum of mice. The windows maintain transparency for over 5 months and allow multi-scale two-photon imaging of neuronal structures and functions in awake mice.

Large-area two-dimensional materials can be transferred at low temperatures and without solvents using conformable tapes whose adhesive force varies with ultraviolet illumination, allowing transfer to various planar and non-planar substrates.

Understanding how proteins and materials interact is useful for evaluating their safety and function. This protocol describes a dimethyl labeling strategy for determining the protein-material interface and discovering allosteric structural changes.

Tapes whose adhesive force is controlled by ultraviolet illumination can be used to cleanly transfer large-area graphene, molybdenum disulfide and other two-dimensional materials with a low thermal budget and using no organic solvents.

An article in Nano Letters presents a method to transfer metallic nanopatterns to soft matter such as tissues or single cells.

A strategy that uses nanoconjugates to label solid cancer cells with the hematopoietic cell-specific molecule SLAMF7, broadens the scope of cancer types susceptible to immune-based anti-cancer therapies and could provide a new approach to treat solid cancers.

Monoclonal antibodies have shown tremendous success in cancer treatment; however, humanization for clinical applications is expensive and not straightforward. Now, molecularly imprinted polymer nanogels have been developed that can block cell-surface proteins and disrupt tumour spheroids.

The in situ, nanoscale positioning of a single molecule below the diffraction limit remains a challenge for chemists. Now, two approaches show how this can be accomplished through a combination of super-resolution microscopy and photo-inducible crosslinking chemistry.

Particle nanofeatures activate the inflammasome and influence immunity.