Peptide condensates are known to regulate compartmentalized enzymatic reactions, however, the influence of condensate chemical composition on enzymatic reactions is still poorly understood. Here, the authors study β-galactosidase as a simple enzymatic model and reveal that product formation is enhanced in heterotypic peptide-RNA condensates, but the reaction is restricted in homotypic peptide condensates.
- Rif Harris
- Shirel Veretnik
- Ayala Lampel