Myelopoiesis

Definition

Myelopoiesis is the process in which innate immune cells, such as neutrophils, dendritic cells and monocytes, develop from a myeloid progenitor cell.

Latest Research and Reviews

News and Comment

  • News and Views |

    The ability to expand and contract populations of myeloid and lymphoid cells during emergency hematopoiesis helps shape the immune response. The expression of intracellular and soluble forms of osteopontin regulates apoptosis thresholds differently in myeloid cells and lymphoid cells to counter infection.

    • Motti Gerlic
    •  & Ben A Croker
    Nature Immunology 18, 953–954
  • News and Views |

    Increased expression of the ubiquitin ligase TRAF6 in hematopoietic stem cells promotes activity of the GTP-binding protein Cdc42 and consequent diminished function of hematopoietic stem cells by ubiquitination of the RNA-binding protein hnRNP-A1, which leads to an inability to properly process pre-mRNA encoding Cdc42-inhibitory GTPase-activating proteins.

    • Martin Turner
    •  & Elisa Monzón-Casanova
    Nature Immunology 18, 146–148
  • News and Views |

    The epigenetic regulation of gene expression by the histone demethylase UTX is central to the development of invariant natural killer cells.

    • S Harsha Krovi
    •  & Laurent Gapin
    Nature Immunology 18, 148–150