Myelopoiesis is the process in which innate immune cells, such as neutrophils, dendritic cells and monocytes, develop from a myeloid progenitor cell.

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  • News and Views |

    Increased expression of the ubiquitin ligase TRAF6 in hematopoietic stem cells promotes activity of the GTP-binding protein Cdc42 and consequent diminished function of hematopoietic stem cells by ubiquitination of the RNA-binding protein hnRNP-A1, which leads to an inability to properly process pre-mRNA encoding Cdc42-inhibitory GTPase-activating proteins.

    • Martin Turner
    •  & Elisa Monzón-Casanova
    Nature Immunology 18, 146–148
  • News and Views |

    The epigenetic regulation of gene expression by the histone demethylase UTX is central to the development of invariant natural killer cells.

    • S Harsha Krovi
    •  & Laurent Gapin
    Nature Immunology 18, 148–150
  • News and Views |

    Single-cell transcriptome analysis has identified progenitor populations with mast-cell and eosinophil potential that are distinct from the neutrophil-monocyte lineage, segregate early in hematopoietic development and can be discriminated by expression of the transcription factor GATA-1.

    • Sandrine Sarrazin
    •  & Michael H Sieweke
    Nature Immunology 17, 609–611