Mutagenesis

Mutagenesis is the process of generating a genetic mutation. This may occur spontaneously or be induced by mutagens. Researchers also use a number of techniques to create mutations, including transposon mutagenesis to generate random gene knockouts, and site-directed mutagenesis, which utilises the polymerase chain reaction to introduce specific mutations.

Latest Research and Reviews

  • Research | | open

    Bret Moore et al. from the International Mouse Phenotyping Consortium report the identification of 347 mouse genes that influence ocular phenotypes when knocked out. 75% of the identified genes have not previously been associated with any ocular pathology.

    • Bret A. Moore
    • , Brian C. Leonard
    • , Lionel Sebbag
    • , Sydney G. Edwards
    • , Ann Cooper
    • , Denise M. Imai
    • , Ewan Straiton
    • , Luis Santos
    • , Christopher Reilly
    • , Stephen M. Griffey
    • , Lynette Bower
    • , David Clary
    • , Jeremy Mason
    • , Michel J. Roux
    • , Hamid Meziane
    • , Yann Herault
    • , Anna Swan
    • , Ruairidh King
    • , Piia Keskivali-Bond
    • , Lois Kelsey
    • , Igor Vukobradovic
    • , Dawei Qu
    • , Ruolin Guo
    • , Elisa Tran
    • , Lily Morikawa
    • , Milan Ganguly
    • , Napoleon Law
    • , Xueyuan Shang
    • , Patricia Feugas
    • , Yanchun Wang
    • , Yingchun Zhu
    • , Kyle Duffin
    • , Ayexa Ramirez
    • , Patricia Penton
    • , Valerie Laurin
    • , Shannon Clarke
    • , Qing Lan
    • , Gillian Sleep
    • , Amie Creighton
    • , Elsa Jacob
    • , Ozge Danisment
    • , Joanna Joeng
    • , Marina Gertsenstein
    • , Monica Pereira
    • , Sue MacMaster
    • , Sandra Tondat
    • , Tracy Carroll
    • , Jorge Cabezas
    • , Amit Patel
    • , Jane Hunter
    • , Gregory Clark
    • , Mohammed Bubshait
    • , David Miller
    • , Khondoker Sohel
    • , Alexandr Bezginov
    • , Matthew McKay
    • , Kevin Peterson
    • , Leslie Goodwin
    • , Rachel Urban
    • , Susan Kales
    • , Rob Hallett
    • , Dong Nguyen-Bresinsky
    • , Timothy Leach
    • , Audrie Seluke
    • , Sara Perkins
    • , Amanda Slater
    • , Rick Bedigian
    • , Leah Rae Donahue
    • , Robert Taft
    • , James Denegre
    • , Zachery Seavey
    • , Amelia Willett
    • , Lindsay Bates
    • , Leslie Haynes
    • , Julie Creed
    • , Catherine Witmeyer
    • , Willson Roper
    • , James Clark
    • , Pamela Stanley
    • , Samantha Burrill
    • , Jennifer Ryan
    • , Yuichi Obata
    • , Masaru Tamura
    • , Hideki Kaneda
    • , Tamio Furuse
    • , Kimio Kobayashi
    • , Ikuo Miura
    • , Ikuko Yamada
    • , Hiroshi Masuya
    • , Nobuhiko Tanaka
    • , Shinya Ayabe
    • , Atsushi Yoshiki
    • , Francesco Chiani
    • , Chiara Di Pietro
    • , Gianfranco Di Segni
    • , Olga Ermakova
    • , Filomena Ferrara
    • , Paolo Fruscoloni
    • , Alessia Gambadoro
    • , Serena Gastaldi
    • , Elisabetta Golini
    • , Gina La Sala
    • , Silvia Mandillo
    • , Daniela Marazziti
    • , Marzia Massimi
    • , Rafaele Matteoni
    • , Tiziana Orsini
    • , Miriam Pasquini
    • , Marcello Raspa
    • , Aline Rauch
    • , Gianfranco Rossi
    • , Nicoletta Rossi
    • , Sabrina Putti
    • , Ferdinando Scavizzi
    • , Giuseppe D. Tocchini-Valentini
    • , Colin McKerlie
    • , Ann M. Flenniken
    • , Lauryl M. J. Nutter
    • , Zorana Berberovic
    • , Celeste Owen
    • , Susan Newbigging
    • , Hibret Adissu
    • , Mohammed Eskandarian
    • , Chih-Wei Hsu
    • , Sowmya Kalaga
    • , Uchechukwu Udensi
    • , Chinwe Asomugha
    • , Ritu Bohat
    • , Juan J. Gallegos
    • , John R. Seavitt
    • , Jason D. Heaney
    • , Arthur L. Beaudet
    • , Mary E. Dickinson
    • , Monica J. Justice
    • , Vivek Philip
    • , Vivek Kumar
    • , Karen L. Svenson
    • , Robert E. Braun
    • , Sara Wells
    • , Heather Cater
    • , Michelle Stewart
    • , Sharon Clementson-Mobbs
    • , Russell Joynson
    • , Xiang Gao
    • , Tomohiro Suzuki
    • , Shigeharu Wakana
    • , Damian Smedley
    • , J. K Seong
    • , Glauco Tocchini-Valentini
    • , Mark Moore
    • , Colin Fletcher
    • , Natasha Karp
    • , Ramiro Ramirez-Solis
    • , Jacqueline K. White
    • , Martin Hrabe de Angelis
    • , Wolfgang Wurst
    • , Sara M. Thomasy
    • , Paul Flicek
    • , Helen Parkinson
    • , Steve D. M. Brown
    • , Terrence F. Meehan
    • , Patsy M. Nishina
    • , Stephen A. Murray
    • , Mark P. Krebs
    • , Ann-Marie Mallon
    • , K. C. Kent Lloyd
    • , Christopher J. Murphy
    •  & Ala Moshiri

News and Comment