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Multicellular systems are living organisms that are composed of numerous interacting cells. In synthetic biology, multicellularity allows some degree of modularity in the combination of elementary functions performed by separate cells.
Single-molecule fluorescence in situ hybridization is performed to identify several landmark genes in the liver and their level of expression in single-cell RNA sequencing is used to spatially reconstruct the zonation of all liver genes.
Cells in dense bacterial suspensions can self-organize into highly robust collective oscillatory motion, while individual cells move in an erratic manner; their interaction is modelled to reveal a weak synchronization mechanism.