Mucosal immunology

Mucosal immunology is the study of immune responses that occur at mucosal surfaces, such as the intestines, the urogenital tract and the lungs. These tissues are closely associated with the external environment and the mucosal immune system must provide protective immunity to pathogens but remain tolerant of non-harmful environmental substances.

Latest Research and Reviews

  • Research |

    Single-cell transcriptomics reveals immune and stromal compartment remodeling, including the enrichment of unique populations of epithelial cells and CD4+ T cells, in asthmatic lungs

    • Felipe A. Vieira Braga
    • , Gozde Kar
    • , Marijn Berg
    • , Orestes A. Carpaij
    • , Krzysztof Polanski
    • , Lukas M. Simon
    • , Sharon Brouwer
    • , Tomás Gomes
    • , Laura Hesse
    • , Jian Jiang
    • , Eirini S. Fasouli
    • , Mirjana Efremova
    • , Roser Vento-Tormo
    • , Carlos Talavera-López
    • , Marnix R. Jonker
    • , Karen Affleck
    • , Subarna Palit
    • , Paulina M. Strzelecka
    • , Helen V. Firth
    • , Krishnaa T. Mahbubani
    • , Ana Cvejic
    • , Kerstin B. Meyer
    • , Kourosh Saeb-Parsy
    • , Marjan Luinge
    • , Corry-Anke Brandsma
    • , Wim Timens
    • , Ilias Angelidis
    • , Maximilian Strunz
    • , Gerard H. Koppelman
    • , Antoon J. van Oosterhout
    • , Herbert B. Schiller
    • , Fabian J. Theis
    • , Maarten van den Berge
    • , Martijn C. Nawijn
    •  & Sarah A. Teichmann
  • Research | | open

    Emily Wong et al. observe that Mycobacterium tuberculosis (Mtb) infection induces recruitment and expansion of a CD8+ TRAV1-2+ T-cell population in the airways of human patients. T cell receptor analysis showed expansion of this cell population, including oligoclonal MAIT cells, in sites where Mtb antigens are present, suggesting they act as sentinels of pulmonary infection.

    • Emily B. Wong
    • , Marielle C. Gold
    • , Erin W. Meermeier
    • , Bongiwe Z. Xulu
    • , Sharon Khuzwayo
    • , Zuri A. Sullivan
    • , Eisa Mahyari
    • , Zoe Rogers
    • , Hénrik Kløverpris
    • , Prabhat K. Sharma
    • , Aneta H. Worley
    • , Umesh Lalloo
    • , Prinita Baijnath
    • , Anish Ambaram
    • , Leon Naidoo
    • , Moosa Suleman
    • , Rajhmun Madansein
    • , James E. McLaren
    • , Kristin Ladell
    • , Kelly L. Miners
    • , David A. Price
    • , Samuel M. Behar
    • , Morten Nielsen
    • , Victoria O. Kasprowicz
    • , Alasdair Leslie
    • , William R. Bishai
    • , Thumbi Ndung’u
    •  & David M. Lewinsohn
  • Research | | open

    Microbiota impacts all major aspects of physiology, but little is known about its effects on age-related changes in immune responses. Here the authors show that gut microbiota transfer between adult and old mice increases local but not systemic germinal centre responses regardless of age directionality.

    • Marisa Stebegg
    • , Alyssa Silva-Cayetano
    • , Silvia Innocentin
    • , Timothy P. Jenkins
    • , Cinzia Cantacessi
    • , Colin Gilbert
    •  & Michelle A. Linterman
  • Research | | open

    Gut lumen antigens must be continuously sampled by the immune system to maintain proper immune homeostasis. Here the authors show that activated CCR6+CCR1+GL7- gut B cells retrieve lumen antigens from specialized M cells and transfer them across the subepithelial dome in the Peyer’s patch to contribute to the maintenance of gut humoral immunity.

    • Rathan Joy Komban
    • , Anneli Strömberg
    • , Adi Biram
    • , Jakob Cervin
    • , Cristina Lebrero-Fernández
    • , Neil Mabbott
    • , Ulf Yrlid
    • , Ziv Shulman
    • , Mats Bemark
    •  & Nils Lycke

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