Motor neuron disease

Motor neuron disease usually refers to amyotrophic lateral sclerosis, but it can also refer to other kind of neurodegenerative disease that affect the motor neurons, such as progressive primary lateral sclerosis, progressive muscular atrophy and progressive bulpar palsy.

Latest Research and Reviews

  • Research | | open

    • Robert Kueffner
    • , Neta Zach
    • , Maya Bronfeld
    • , Raquel Norel
    • , Nazem Atassi
    • , Venkat Balagurusamy
    • , Barbara Di Camillo
    • , Adriano Chio
    • , Merit Cudkowicz
    • , Donna Dillenberger
    • , Javier Garcia-Garcia
    • , Orla Hardiman
    • , Bruce Hoff
    • , Joshua Knight
    • , Melanie L. Leitner
    • , Guang Li
    • , Lara Mangravite
    • , Thea Norman
    • , Liuxia Wang
    • , Rached Alkallas
    • , Catalina Anghel
    • , Jeanne Avril
    • , Jaume Bacardit
    • , Barbara Balser
    • , John Balser
    • , Yoav Bar-Sinai
    • , Noa Ben-David
    • , Eyal Ben-Zion
    • , Robin Bliss
    • , Jialu Cai
    • , Anatoly Chernyshev
    • , Jung-Hsien Chiang
    • , Davide Chicco
    • , Bhavna Ahuja Nicole Corriveau
    • , Junqiang Dai
    • , Yash Deshpande
    • , Eve Desplats
    • , Joseph S. Durgin
    • , Shadrielle Melijah G. Espiritu
    • , Fan Fan
    • , Philippe Fevrier
    • , Brooke L. Fridley
    • , Adam Godzik
    • , Agnieszka Golińska
    • , Jonathan Gordon
    • , Stefan Graw
    • , Yuelong Guo
    • , Tim Herpelinck
    • , Julia Hopkins
    • , Barbara Huang
    • , Jeremy Jacobsen
    • , Samad Jahandideh
    • , Jouhyun Jeon
    • , Wenkai Ji
    • , Kenneth Jung
    • , Alex Karanevich
    • , Devin C. Koestler
    • , Michael Kozak
    • , Christoph Kurz
    • , Christopher Lalansingh
    • , Thomas Larrieu
    • , Nicola Lazzarini
    • , Boaz Lerner
    • , Wojciech Lesinski
    • , Xiaotao Liang
    • , Xihui Lin
    • , Jarrett Lowe
    • , Lester Mackey
    • , Richard Meier
    • , Wenwen Min
    • , Krzysztof Mnich
    • , Violette Nahmias
    • , Janelle Noel-MacDonnell
    • , Adrienne O’Donnell
    • , Susan Paadre
    • , Ji Park
    • , Aneta Polewko-Klim
    • , Rama Raghavan
    • , Witold Rudnicki
    • , Ehsan Saghapour
    • , Jean-Bernard Salomond
    • , Kris Sankaran
    • , Dorota Sendorek
    • , Vatsal Sharan
    • , Yu-Jia Shiah
    • , Jean-Karl Sirois
    • , Dinithi N. Sumanaweera
    • , Joseph Usset
    • , Yeeleng S. Vang
    • , Celine Vens
    • , Dave Wadden
    • , David Wang
    • , Wing Chung Wong
    • , Xiaohui Xie
    • , Zhiqing Xu
    • , Hsih-Te Yang
    • , Xiang Yu
    • , Haichen Zhang
    • , Li Zhang
    • , Shihua Zhang
    • , Shanfeng Zhu
    • , Jinfeng Xiao
    • , Wen-Chieh Fang
    • , Jian Peng
    • , Chen Yang
    • , Huan-Jui Chang
    •  & Gustavo Stolovitzky
  • Research |

    Klim et al. illuminate pathomechanisms of ALS using pluripotent stem cells to identify transcripts altered in human motor neurons by perturbations to ALS protein TDP-43, finding the microtubule regulator STMN2 highly sensitive to TDP-43 malfunctions.

    • Joseph R. Klim
    • , Luis A. Williams
    • , Francesco Limone
    • , Irune Guerra San Juan
    • , Brandi N. Davis-Dusenbery
    • , Daniel A. Mordes
    • , Aaron Burberry
    • , Michael J. Steinbaugh
    • , Kanchana K. Gamage
    • , Rory Kirchner
    • , Rob Moccia
    • , Seth H. Cassel
    • , Kuchuan Chen
    • , Brian J. Wainger
    • , Clifford J. Woolf
    •  & Kevin Eggan
    Nature Neuroscience 22, 167-179
  • Research |

    The mRNA encoding stathmin-2, a protein implicated in axonal growth, is shown to be widely suppressed by premature polyadenylation in both sporadic and C9orf72 ALS through a mechanism directly dependent on loss of nuclear TDP-43 in motor neurons.

    • Ze’ev Melamed
    • , Jone López-Erauskin
    • , Michael W. Baughn
    • , Ouyang Zhang
    • , Kevin Drenner
    • , Ying Sun
    • , Fernande Freyermuth
    • , Moira A. McMahon
    • , Melinda S. Beccari
    • , Jon W. Artates
    • , Takuya Ohkubo
    • , Maria Rodriguez
    • , Nianwei Lin
    • , Dongmei Wu
    • , C. Frank Bennett
    • , Frank Rigo
    • , Sandrine Da Cruz
    • , John Ravits
    • , Clotilde Lagier-Tourenne
    •  & Don W. Cleveland
    Nature Neuroscience 22, 180-190
  • Protocols |

    This protocol describes how to inject therapeutic cells, viruses, or other macromolecular products into the mouse or rat lumbar ventral cord, modeling the routes used for administration of therapies currently in use in human clinical trials.

    • Kevin S. Chen
    • , Lisa M. McGinley
    • , Osama N. Kashlan
    • , John M. Hayes
    • , Elizabeth S. Bruno
    • , Josh S. Chang
    • , Faye E. Mendelson
    • , Maegan A. Tabbey
    • , Karl Johe
    • , Stacey A. Sakowski
    •  & Eva L. Feldman
    Nature Protocols 14, 331-349

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