Morphogenesis

Definition

Morphogenesis is the process by which an organism, tissue or organ develops its shape. Morphogenesis is driven by various cellular and developmental processes including cell proliferation, differentiation, apoptosis, cell migration and cell adhesion.

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Latest Research and Reviews

  • Research | | open

    Polarized epithelial cells must correctly position a wide range of subcellular structures. Here the authors demonstrate an apicobasal gradient of Rac GTPase activity, which is maintained by polarity proteins in Drosophila epithelial sheets, and is required to maintain actin-dependent protrusion form and position.

    • Africa Couto
    • , Natalie Ann Mack
    • , Lucrezia Favia
    •  & Marios Georgiou
  • Research | | open

    Large-scale tissue reorganization requires the generation of directional tension, which requires orientation of the cytoskeleton. Here Chanet et al. alter tissue shape and tension in the Drosophila embryo to show that geometric and mechanical constraints act as cues to orient the cytoskeleton and tension.

    • Soline Chanet
    • , Callie J. Miller
    • , Eeshit Dhaval Vaishnav
    • , Bard Ermentrout
    • , Lance A. Davidson
    •  & Adam C. Martin
  • Research |

    Bower et al. describe a population of mural lymphatic endothelial cells found along meningeal blood vessels in the adult zebrafish. These mural cells are distinct from meningeal lymphatic vessel cells but form by developmental lymphangiogenesis. They take up low-density lipoproteins from the bloodstream and can modulate angiogenesis during meningeal vascularization.

    • Neil I Bower
    • , Katarzyna Koltowska
    • , Cathy Pichol-Thievend
    • , Isaac Virshup
    • , Scott Paterson
    • , Anne K Lagendijk
    • , Weili Wang
    • , Benjamin W Lindsey
    • , Stephen J Bent
    • , Sungmin Baek
    • , Maria Rondon-Galeano
    • , Daniel G Hurley
    • , Naoki Mochizuki
    • , Cas Simons
    • , Mathias Francois
    • , Christine A Wells
    • , Jan Kaslin
    •  & Benjamin M Hogan
    Nature Neuroscience 20, 774–783
  • Research | | open

    Common mechanisms underlie organ regeneration, but it is unclear if the same regulatory elements are activated in distinct cells, such as cardiomyocytes and fibroblasts. Here, the authors identify a ctgfa upstream sequence, called careg, induced by TGFb/Activin during zebrafish heart and fin regeneration.

    • Catherine Pfefferli
    •  & Anna Jaźwińska
  • Research | | open

    Quantifying deformation patterns of curved epithelial sheets is challenging owing to imaging difficulties. Here the authors develop a method to obtain a quantitative description of 3D tissue deformation dynamics from a small set of cell positional data and applied it to chick forebrain morphogenesis.

    • Yoshihiro Morishita
    • , Ken-ichi Hironaka
    • , Sang-Woo Lee
    • , Takashi Jin
    •  & Daisuke Ohtsuka

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