Monocytes and macrophages

Definition

Monocytes and macrophages are myeloid cells that have important innate immune functions. Macrophages reside in tissues and respond to infection by producing inflammatory mediators and engulfing bacteria. Monocytes are recruited to inflamed tissues and can produce inflammatory mediators or differentiate into macrophages. Both cells types can also promote tissue repair.

Latest Research and Reviews

  • Research | | open

    Glucocorticoid reduces inflammation by both inducing anti-inflammatory genes and suppressing pro-inflammatory genes, but how these two functions are dictated is unclear. Here the authors show that phosphorylated glucocorticoid receptor-interacting protein 1 (GRIP1) serves as a coactivator for this response in macrophage.

    • David A. Rollins
    • , Joubert B. Kharlyngdoh
    • , Maddalena Coppo
    • , Bowranigan Tharmalingam
    • , Sanda Mimouna
    • , Ziyi Guo
    • , Maria A. Sacta
    • , Miles A. Pufall
    • , Robert P. Fisher
    • , Xiaoyu Hu
    • , Yurii Chinenov
    •  & Inez Rogatsky
  • Research | | open

    Complement component C1q activates efferocytosis, suppresses inflammatory responses, and is thereby thought to limit autoimmune disease. Here, the authors show that macrophage transcription factor MafB regulates total serum levels of C1q, which contributes to preventing autoimmune disease in mice.

    • Mai Thi Nhu Tran
    • , Michito Hamada
    • , Hyojung Jeon
    • , Risako Shiraishi
    • , Keigo Asano
    • , Motochika Hattori
    • , Megumi Nakamura
    • , Yuki Imamura
    • , Yuki Tsunakawa
    • , Risa Fujii
    • , Toshiaki Usui
    • , Kaushalya Kulathunga
    • , Christina-Sylvia Andrea
    • , Ryusuke Koshida
    • , Risa Kamei
    • , Yurina Matsunaga
    • , Makoto Kobayashi
    • , Hisashi Oishi
    • , Takashi Kudo
    •  & Satoru Takahashi
  • Reviews |

    This Review describes recent advances in our understanding of the ontogeny, development and function of brain-resident macrophages and microglia, including their normal functions during brain development and homeostasis and how disturbance of these functions may precipitate neurodegenerative and neuropsychiatric diseases.

    • Qingyun Li
    •  & Ben A. Barres
  • Research | | open

    Macrophage differentiation and inflammatory function are controlled by cell metabolism. Here, the authors use a viral hepatitis model and a high-fat diet model of insulin resistance to show how VSIG4 inhibits inflammatory macrophage activation by modulating mitochondrial pyruvate metabolism.

    • Jialin Li
    • , Bo Diao
    • , Sheng Guo
    • , Xiaoyong Huang
    • , Chengying Yang
    • , Zeqing Feng
    • , Weiming Yan
    • , Qin Ning
    • , Lixin Zheng
    • , Yongwen Chen
    •  & Yuzhang Wu
  • Research |

    Gillet and colleagues find that infection with a gammaherpesvirus confers strong and lasting protection against airway allergy through the replacement of lung-resident alveolar macrophages with recruited regulatory monocytes of bone marrow origin.

    • Bénédicte Machiels
    • , Mickael Dourcy
    • , Xue Xiao
    • , Justine Javaux
    • , Claire Mesnil
    • , Catherine Sabatel
    • , Daniel Desmecht
    • , François Lallemand
    • , Philippe Martinive
    • , Hamida Hammad
    • , Martin Guilliams
    • , Benjamin Dewals
    • , Alain Vanderplasschen
    • , Bart N Lambrecht
    • , Fabrice Bureau
    •  & Laurent Gillet
    Nature Immunology 18, 1310–1320

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