Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Molecular fluctuations are random changes of molecular parameters such as conformation or concentration. In living cells, molecular fluctuations are a source of heterogeneity among cells sharing a common genetic background.
Combined transcriptomics and proteomics of skin and lymphoid organs reveal the significance of SPINK5 in the regulation of protease activity and systemic inflammation, providing a conserved molecular framework for Netherton syndrome.
Signalling responses are marked by substantial cell-to-cell variability. Here, the authors propose an information theoretic framework that accounts for multiple inputs and temporal dynamics to analyse how signals flow through shared network components.
A diet-controlled study indicates that metabolic flexibility is an important driver of inter-individual difference in the response to dietary change, and a high flexibility score is a likely health asset.
