Molecular biology

Molecular Biology is the field of biology that studies the composition, structure and interactions of cellular molecules – such as nucleic acids and proteins – that carry out the biological processes essential for the cell’s functions and maintenance.

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Latest Research and Reviews

  • Research | | open

    In fission yeast, Erh1, ortholog of human ERH, interacts with the YTH family RNA binding protein Mmi1 to form the Erh1-Mmi1 complex (EMC), which has been implicated in gene silencing. Here, the authors present the cocrystal structure of Erh1 homodimers interacting with Mmi1 and further characterise the role of EMC in facultative heterochromatin assembly and gene silencing.

    • Guodong Xie
    • , Tommy V. Vo
    • , Gobi Thillainadesan
    • , Sahana Holla
    • , Beibei Zhang
    • , Yiyang Jiang
    • , Mengqi Lv
    • , Zheng Xu
    • , Chongyuan Wang
    • , Vanivilasini Balachandran
    • , Yunyu Shi
    • , Fudong Li
    •  & Shiv I. S. Grewal
  • Research | | open

    The humoral immune response role in cancer is unclear. Here the authors perform an in-depth proteomic profiling of immunoglobulin-bound proteins in plasma from pancreatic ductal adenocarcinoma patients and find cancer-cell specific antibodies neutralized by binding to cancer-cell derived exosomes.

    • Michela Capello
    • , Jody V. Vykoukal
    • , Hiroyuki Katayama
    • , Leonidas E. Bantis
    • , Hong Wang
    • , Deepali L. Kundnani
    • , Clemente Aguilar-Bonavides
    • , Mitzi Aguilar
    • , Satyendra C. Tripathi
    • , Dilsher S. Dhillon
    • , Amin A. Momin
    • , Haley Peters
    • , Matthew H. Katz
    • , Hector Alvarez
    • , Vincent Bernard
    • , Sammy Ferri-Borgogno
    • , Randall Brand
    • , Douglas G. Adler
    • , Matthew A. Firpo
    • , Sean J. Mulvihill
    • , Jeffrey J. Molldrem
    • , Ziding Feng
    • , Ayumu Taguchi
    • , Anirban Maitra
    •  & Samir M. Hanash
  • Research | | open

    Oxidative DNA damage is associated with nucleosome respacing and transcriptional changes requiring chromatin remodeling enzymes. Here, the authors reveal that the CHD6 remodeler is a DNA damage response factor that relocates to damaged sites and promotes cell survival following oxidative damage.

    • Shaun Moore
    • , N. Daniel Berger
    • , Martijn S. Luijsterburg
    • , Cortt G. Piett
    • , Fintan K. T. Stanley
    • , Christoph U. Schräder
    • , Shujuan Fang
    • , Jennifer A. Chan
    • , David C. Schriemer
    • , Zachary D. Nagel
    • , Haico van Attikum
    •  & Aaron A. Goodarzi
  • Research |

    Transcriptomic and genetic analyses of a deletion set of all known introns in genes of the budding yeast Saccharomyces cerevisiae indicate that introns promote resistance to starvation.

    • Julie Parenteau
    • , Laurine Maignon
    • , Mélodie Berthoumieux
    • , Mathieu Catala
    • , Vanessa Gagnon
    •  & Sherif Abou Elela
    Nature, 1-6

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