miRNA in immune cells

MicroRNAs (miRNAs) are small, ribonucleic acid (RNA) molecules that regulate gene expression by binding to specific messenger RNAs (mRNAs). In immune cells, miRNAs have been reported to regulate cell development, cell differentiation and the production of inflammatory mediators.

Latest Research and Reviews

News and Comment

  • News and Views |

    Innate lymphoid cell–derived cytokine IL-13 promotes the maintenance of intestinal stem cells through stabilization of β-catenin. The circular RNA circPan3 regulates mRNA encoding the cytokine receptor subunit IL-13Rα and downstream IL-13 signaling to stabilize the β-catenin pathway in intestinal stem cells.

    • Frank Soveg
    • , Jakob von Moltke
    •  & Ram Savan
    Nature Immunology 20, 114-116
  • News and Views |

    Cell-type-specific regulation of gene expression by transcription factors is a fundamental principle of biology. New findings show that microRNA-mediated control of target-gene expression is also dependent on the cellular context.

    • Pengda Chen
    • , Kunyu Liao
    •  & Changchun Xiao
    Nature Immunology 19, 1040-1042
  • News and Views |

    What keeps memory T cells functionally silent in the absence of infection is unclear. New data reveal the existence of a deterministic halt in the protein-synthesis machinery of memory T cells and expose the discriminatory functions of a family of RNA-binding proteins.

    • Dimitris L. Kontoyiannis
    Nature Immunology 19, 795-797
  • News and Views |

    The RNA endonuclease Drosha is required for myelopoiesis by its direct cleavage of stem-loop structures in mRNAs encoding Myl9 and Todr1.

    • Annemarthe G van der Veen
    • , Pierre V Maillard
    •  & Caetano Reis e Sousa
    Nature Immunology 16, 1110-1112