Microwave chemistry articles from across Nature Portfolio

Latest Research and Reviews

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  Total wash elimination for solid phase peptide synthesis

  Peptide drug manufacturing commonly uses large amounts of hazardous solvents primarily due to multiple washings after each step. Here, the authors introduce the concept of a completely wash-free methodology that enables up to 95% waste reduction.

  • Jonathan M. Collins
  • Sandeep K. Singh
  • Christopher L. Houser

  ResearchOpen Access09 Dec 2023 Nature Communications

  Volume: 14, P: 8168
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  Three-dimensional observations of the electric field distribution of variable frequency microwaves, and scaling-up organic syntheses

  The variable frequency microwave (VFM) technology is known for its theoretically uniform microwave E-field distribution, although the experimental distribution remains poorly understood. Here, the authors examine the effectiveness of VFM irradiation experimentally by in situ 3D observation of the E-field, and apply VFM to the large scale synthesis of 4-methylbiphenyl via the Suzuki-Miyaura cross-coupling reaction catalyzed by solid Pd supported on activated carbon particulates.

  • Satoshi Horikoshi
  • Haruka Mura
  • Nick Serpone

  ResearchOpen Access29 Nov 2023 Communications Chemistry

  Volume: 6, P: 261
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  Effect of linearly polarized microwaves on nanomorphology of calcium carbonate mineralization using peptides

  • Kenji Usui
  • Makoto Ozaki
  • Fumihiro Kayamori

  ResearchOpen Access25 Jul 2023 Scientific Reports

  Volume: 13, P: 12027
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  Microwave-assisted C–C bond formation of diarylacetylenes and aromatic hydrocarbons on carbon beads under continuous-flow conditions

  The synthesis of polycyclic aromatic compounds generally requires stoichiometric oxidants or homogeneous metal catalysts, however, the risk of contamination of inorganic residues can affect their properties. Here, the authors develop a microwave-assisted platinum on beaded activated carbon-catalyzed C–C bond formation of aromatic compounds under continuous-flow conditions.

  • Tsuyoshi Yamada
  • Wataru Teranishi
  • Hironao Sajiki

  ResearchOpen Access24 Apr 2023 Communications Chemistry

  Volume: 6, P: 78
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  Using genetic algorithms to systematically improve the synthesis conditions of Al-PMOF

  Metal-organic frameworks with desirable properties can be designed through careful choice of linker and node combinations, but achieving the synthesis of a desired MOF is complex and dependent on many experimental variables. Here, a genetic algorithm combined with experimental feedback and confirmation is used to obtain the optimal microwave-assisted synthesis conditions for a porphyrin-based aluminium MOF (Al-PMOF), achieving excellent crystallinity and a close to 80% yield in only the 2^nd generation.

  • Nency P. Domingues
  • Seyed Mohamad Moosavi
  • Berend Smit

  ResearchOpen Access10 Dec 2022 Communications Chemistry

  Volume: 5, P: 170
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  An acceleration of microwave-assisted transesterification of palm oil-based methyl ester into trimethylolpropane ester

  • Nur Atiqah Mohamad Aziz
  • Robiah Yunus
  • Zulkifly Abbas

  ResearchOpen Access12 Nov 2020 Scientific Reports

  Volume: 10, P: 19652