Microscopy articles from across Nature Portfolio

We created DELiVR, a deep-learning pipeline for 3D brain-cell mapping that is trained with virtual reality-generated reference annotations. It can be deployed via the user-friendly interface of the open-source software Fiji, which makes the analysis of large-scale 3D brain images widely accessible to scientists without computational expertise.

The sensing of bitter taste results from the complex interplay of many chemical cues and a range of receptors. It emerges that this complexity might be built-in even at the level of individual receptors.

A non-common-path interferometric scheme enables holographic detection of single proteins of mass 90 kDa and estimation of single-protein polarizability.

Electrochemical control of the switching of fluorophores in stochastic optical reconstruction microscopy (EC-STORM) enables the counting of single fluorophores as well as cell imaging with improved spatial resolution and reduced artefacts compared with traditional STORM.

Wide-field mid-infrared photothermal imaging is developed to supress the resolution degradation caused by photo-thermal heat diffusion. By employing a single-objective synthetic-aperture imaging with synchronized subnanosecond mid-infrared and visible light sources, spatial resolution of 120 nm is obtained.

Random-access wide-field mesoscopy enables the imaging of in vivo biodynamics in mice over an area of 160 mm² and at a subcellular spatial resolution of about 2 μm.

We created DELiVR, a deep-learning pipeline for 3D brain-cell mapping that is trained with virtual reality-generated reference annotations. It can be deployed via the user-friendly interface of the open-source software Fiji, which makes the analysis of large-scale 3D brain images widely accessible to scientists without computational expertise.

The sensing of bitter taste results from the complex interplay of many chemical cues and a range of receptors. It emerges that this complexity might be built-in even at the level of individual receptors.

A non-common-path interferometric scheme enables holographic detection of single proteins of mass 90 kDa and estimation of single-protein polarizability.

A method for imaging the production of blood cells in the bones of mice has revealed the organization of cell lineages, both in a steady state and in response to stressors, such as bleeding and infection.

Artificial intelligence is used to automate the synthesis of single molecules using the tip of a scanning probe microscope, as well as to extract chemical information from these reactions.