Microglia

Microglia are a type of small macrophage-like glial cell in the central nervous system. Microglia can engage in phagocytosis, and are involved in immune responses within, as well as the development and remodelling of the nervous system. Their shape varies depending on the developmental and functional state, and anatomical location.

Latest Research and Reviews

  • Research | | open

    The role of microglia following spinal cord injury is not fully understood. Here, using transgenic approaches to selectively label microglia and not macrophages in mice, the authors show that microglia are highly active and accumulate at the edge of the lesion in the first weeks post injury, and also that inhibiting microglia activation impairs recovery in the early stages after spinal cord injury.

    • Victor Bellver-Landete
    • , Floriane Bretheau
    • , Benoit Mailhot
    • , Nicolas Vallières
    • , Martine Lessard
    • , Marie-Eve Janelle
    • , Nathalie Vernoux
    • , Marie-Ève Tremblay
    • , Tobias Fuehrmann
    • , Molly S. Shoichet
    •  & Steve Lacroix
  • Research |

    Loss of Trem2 function increases early amyloidogenesis by preventing microglial activation and clustering around amyloid seeds. As a consequence of reduced microglial ApoE production in the absence of Trem2 function, amyloid plaques contain less ApoE.

    • Samira Parhizkar
    • , Thomas Arzberger
    • , Matthias Brendel
    • , Gernot Kleinberger
    • , Maximilian Deussing
    • , Carola Focke
    • , Brigitte Nuscher
    • , Monica Xiong
    • , Alireza Ghasemigharagoz
    • , Natalie Katzmarski
    • , Susanne Krasemann
    • , Stefan F. Lichtenthaler
    • , Stephan A. Müller
    • , Alessio Colombo
    • , Laura Sebastian Monasor
    • , Sabina Tahirovic
    • , Jochen Herms
    • , Michael Willem
    • , Nadine Pettkus
    • , Oleg Butovsky
    • , Peter Bartenstein
    • , Dieter Edbauer
    • , Axel Rominger
    • , Ali Ertürk
    • , Stefan A. Grathwohl
    • , Jonas J. Neher
    • , David M. Holtzman
    • , Melanie Meyer-Luehmann
    •  & Christian Haass
    Nature Neuroscience 22, 191-204
  • Research |

    Single-cell mass cytometry was applied to comprehensively characterize postmortem and fresh human microglia. Using a hybrid workflow for multidimensional data analysis, a core signature and regional heterogeneity were identified.

    • Chotima Böttcher
    • , Stephan Schlickeiser
    • , Marjolein A. M. Sneeboer
    • , Desiree Kunkel
    • , Anniki Knop
    • , Evdokia Paza
    • , Pawel Fidzinski
    • , Larissa Kraus
    • , Gijsje J. L. Snijders
    • , René S Kahn
    • , Axel R Schulz
    • , Henrik E Mei
    • , Elly M. Hol
    • , Britta Siegmund
    • , Rainer Glauben
    • , Eike J Spruth
    • , Lot D de Witte
    •  & Josef Priller
  • Research | | open

    Previous studies have shown that depletion of microglia at early developmental stages leads to neuronal death. Here the authors use an inducible system to ablate microglia in adulthood, showing that such depletion leads to ataxia-like behavior and neuronal loss, and identifying the inflammatory components that may contribute.

    • Stephen J. Rubino
    • , Lior Mayo
    • , Isabella Wimmer
    • , Victoria Siedler
    • , Florian Brunner
    • , Simon Hametner
    • , Asaf Madi
    • , Amanda Lanser
    • , Thais Moreira
    • , Dustin Donnelly
    • , Laura Cox
    • , Rafael Machado Rezende
    • , Oleg Butovsky
    • , Hans Lassmann
    •  & Howard L. Weiner

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