Microbiology

Definition

Microbiology is the study of microscopic organisms, such as bacteria, viruses, archaea, fungi and protozoa. This discipline includes fundamental research on the biochemistry, physiology, cell biology, ecology, evolution and clinical aspects of microorganisms, including the host response to these agents.

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Latest Research and Reviews

  • Research |

    A pathway for the production of aromatic amino acid metabolites in Clostridium sporogenes is described; modulation of serum levels of these metabolites in gnotobiotic mice affects intestinal permeability and systemic immunity.

    • Dylan Dodd
    • , Matthew H. Spitzer
    • , William Van Treuren
    • , Bryan D. Merrill
    • , Andrew J. Hryckowian
    • , Steven K. Higginbottom
    • , Anthony Le
    • , Tina M. Cowan
    • , Garry P. Nolan
    • , Michael A. Fischbach
    •  & Justin L. Sonnenburg
  • Research | | open

    Cas9 and Cpf1 have both been adapted for genome engineering, editing and gene expression regulation. Here the authors design a fusion guide RNA that can interact with both proteins for multiple and orthogonal genome manipulation.

    • Jiyeon Kweon
    • , An-Hee Jang
    • , Da-Eun Kim
    • , Jin Wook Yang
    • , Mijung Yoon
    • , Ha Rim Shin
    • , Jin-Soo Kim
    •  & Yongsub Kim
  • Research | | open

    Some bacteria can use inorganic phosphite and hypophosphite as sources of inorganic phosphorus. Here, the authors report crystal structures of the periplasmic proteins that bind these reduced phosphorus species and show that a P-H…π interaction between the ligand and binding site determines their specificity.

    • Claudine Bisson
    • , Nathan B. P. Adams
    • , Ben Stevenson
    • , Amanda A. Brindley
    • , Despo Polyviou
    • , Thomas S. Bibby
    • , Patrick J. Baker
    • , C. Neil Hunter
    •  & Andrew Hitchcock
  • Research | | open

    Using CRISPR to write specific genetic sequences can sometimes be difficult due to the preference of mammalian cells to repair breaks using NHEJ. Here the authors form nanoparticles to localize the template sequence to the nuclease, shifting repair in favor of HDR.

    • Jared Carlson-Stevermer
    • , Amr A. Abdeen
    • , Lucille Kohlenberg
    • , Madelyn Goedland
    • , Kaivalya Molugu
    • , Meng Lou
    •  & Krishanu Saha
  • Research | | open

    An efficient HIV-1 vaccine will likely depend on eliciting broadly neutralizing antibodies (bnAb). Here the authors analyze the B cell repertoire in macaques and knock-in mice in response to sequential immunization with Env variants that induce a bnAb targeting the CD4-binding site of Env in a HIV-1 infected individual.

    • Wilton B. Williams
    • , Jinsong Zhang
    • , Chuancang Jiang
    • , Nathan I. Nicely
    • , Daniela Fera
    • , Kan Luo
    • , M. Anthony Moody
    • , Hua-Xin Liao
    • , S. Munir Alam
    • , Thomas B. Kepler
    • , Akshaya Ramesh
    • , Kevin Wiehe
    • , James A. Holland
    • , Todd Bradley
    • , Nathan Vandergrift
    • , Kevin O. Saunders
    • , Robert Parks
    • , Andrew Foulger
    • , Shi-Mao Xia
    • , Mattia Bonsignori
    • , David C. Montefiori
    • , Mark Louder
    • , Amanda Eaton
    • , Sampa Santra
    • , Richard Scearce
    • , Laura Sutherland
    • , Amanda Newman
    • , Hilary Bouton-Verville
    • , Cindy Bowman
    • , Howard Bomze
    • , Feng Gao
    • , Dawn J. Marshall
    • , John F. Whitesides
    • , Xiaoyan Nie
    • , Garnett Kelsoe
    • , Steven G. Reed
    • , Christopher B. Fox
    • , Kim Clary
    • , Marguerite Koutsoukos
    • , David Franco
    • , John R. Mascola
    • , Stephen C. Harrison
    • , Barton F. Haynes
    •  & Laurent Verkoczy
  • Research | | open

    Coronaviruses have a relatively high mutation rate, potentially allowing fast adaptation to changing pressures. Here, Wong et al. provide the structure of the receptor-binding domain (RBD) of the human coronavirus HCoV-229E and its receptor and analyze the evolution of the RBD over the past 50 years.

    • Alan H. M. Wong
    • , Aidan C. A. Tomlinson
    • , Dongxia Zhou
    • , Malathy Satkunarajah
    • , Kevin Chen
    • , Chetna Sharon
    • , Marc Desforges
    • , Pierre J. Talbot
    •  & James M. Rini

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