Microbiology

Definition

Microbiology is the study of microscopic organisms, such as bacteria, viruses, archaea, fungi and protozoa. This discipline includes fundamental research on the biochemistry, physiology, cell biology, ecology, evolution and clinical aspects of microorganisms, including the host response to these agents.

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Latest Research and Reviews

  • Reviews |

    Lambris and colleagues discuss new and previously unanticipated functions of complement and how these affect immunity and disease pathogenesis.

    • George Hajishengallis
    • , Edimara S Reis
    • , Dimitrios C Mastellos
    • , Daniel Ricklin
    •  & John D Lambris
    Nature Immunology 18, 1288–1298
  • Reviews |

    Hepatitis E virus (HEV) infection is often asymptomatic but can lead to acute and chronic hepatitis as well as to extrahepatic manifestations such as neurological or renal disease and pregnancy complications. In this Primer, Kamar et al. describe the epidemiology, pathophysiology, diagnosis and management of HEV infection.

    • Nassim Kamar
    • , Jacques Izopet
    • , Nicole Pavio
    • , Rakesh Aggarwal
    • , Alain Labrique
    • , Heiner Wedemeyer
    •  & Harry R. Dalton
  • Research |

    Quantitive microbiome profiling reveals that total microbial load is an important determinant of enterotypes and may be a key driver of microbiota alterations in patients with Crohn’s disease.

    • Doris Vandeputte
    • , Gunter Kathagen
    • , Kevin D’hoe
    • , Sara Vieira-Silva
    • , Mireia Valles-Colomer
    • , João Sabino
    • , Jun Wang
    • , Raul Y. Tito
    • , Lindsey De Commer
    • , Youssef Darzi
    • , Séverine Vermeire
    • , Gwen Falony
    •  & Jeroen Raes
  • Research |

    High salt intake changed the gut microbiome and increased TH17 cell numbers in mice, and reduced intestinal survival of Lactobacillus species, increased the number of TH17 cells and increased blood pressure in humans.

    • Nicola Wilck
    • , Mariana G. Matus
    • , Sean M. Kearney
    • , Scott W. Olesen
    • , Kristoffer Forslund
    • , Hendrik Bartolomaeus
    • , Stefanie Haase
    • , Anja Mähler
    • , András Balogh
    • , Lajos Markó
    • , Olga Vvedenskaya
    • , Friedrich H. Kleiner
    • , Dmitry Tsvetkov
    • , Lars Klug
    • , Paul I. Costea
    • , Shinichi Sunagawa
    • , Lisa Maier
    • , Natalia Rakova
    • , Valentin Schatz
    • , Patrick Neubert
    • , Christian Frätzer
    • , Alexander Krannich
    • , Maik Gollasch
    • , Diana A. Grohme
    • , Beatriz F. Côrte-Real
    • , Roman G. Gerlach
    • , Marijana Basic
    • , Athanasios Typas
    • , Chuan Wu
    • , Jens M. Titze
    • , Jonathan Jantsch
    • , Michael Boschmann
    • , Ralf Dechend
    • , Markus Kleinewietfeld
    • , Stefan Kempa
    • , Peer Bork
    • , Ralf A. Linker
    • , Eric J. Alm
    •  & Dominik N. Müller
  • Research | | open

    Neutralizing antibodies to oligomannose glycans on HIV Env are difficult to elicit, possibly due to B cell tolerance. Here, Pantophlet et al. synthesize mimetics based on a bacterial oligosaccharide and show that they evoke HIV-neutralizing antibody responses in animals with a human Ig repertoire.

    • Ralph Pantophlet
    • , Nino Trattnig
    • , Sasha Murrell
    • , Naiomi Lu
    • , Dennis Chau
    • , Caitlin Rempel
    • , Ian A. Wilson
    •  & Paul Kosma

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