MHC

The major histocompatibility complex (MHC) is a cluster of genes encoding molecules that are important for lymphocyte activation. MHC molecules bind small fragments of proteins from inside a cell and present these at the cell surface. By scanning MHC molecules, lymphocytes can assess cells for signs of infection or damage.

Latest Research and Reviews

  • Research | | open

    Anti-human leukocyte antigen (HLA) antibodies are important mediators of alloresponses, but structural insights on antibody:HLA interaction are still lacking. Here the authors provide a 2.4 Å structure of antibody:HLA complex, and also analyse HLA features important for other HLA-interacting molecules, to enhance our understanding of alloimmunity.

    • Yue Gu
    • , Yee Hwa Wong
    • , Chong Wai Liew
    • , Conrad E. Z. Chan
    • , Tanusya M. Murali
    • , Jiawei Yap
    • , Chien Tei Too
    • , Kiren Purushotorman
    • , Maryam Hamidinia
    • , Abbas El Sahili
    • , Angeline T. H. Goh
    • , Rachel Z. C. Teo
    • , Kathryn J. Wood
    • , Brendon J. Hanson
    • , Nicholas R. J. Gascoigne
    • , Julien Lescar
    • , Anantharaman Vathsala
    •  & Paul A. MacAry
  • Research |

    Regulatory T cells suppress target cells through diverse mechanisms. Shevach and colleagues demonstrate that regulatory T cells in vivo strip complexes of cognate peptide and major histocompatibility complex class II from dendritic cells and thereby help to maintain immune homeostasis.

    • Billur Akkaya
    • , Yoshihiro Oya
    • , Munir Akkaya
    • , Jafar Al Souz
    • , Amanda H. Holstein
    • , Olena Kamenyeva
    • , Juraj Kabat
    • , Ryutaro Matsumura
    • , David W. Dorward
    • , Deborah D. Glass
    •  & Ethan M. Shevach
    Nature Immunology 20, 218-231
  • Research |

    Neoantigen prediction from clinical samples is improved using a neural network model trained on a large HLA peptide and genomic tumor dataset.

    • Brendan Bulik-Sullivan
    • , Jennifer Busby
    • , Christine D Palmer
    • , Matthew J Davis
    • , Tyler Murphy
    • , Andrew Clark
    • , Michele Busby
    • , Fujiko Duke
    • , Aaron Yang
    • , Lauren Young
    • , Noelle C Ojo
    • , Kamilah Caldwell
    • , Jesse Abhyankar
    • , Thomas Boucher
    • , Meghan G Hart
    • , Vladimir Makarov
    • , Vincent Thomas De Montpreville
    • , Olaf Mercier
    • , Timothy A Chan
    • , Giorgio Scagliotti
    • , Paolo Bironzo
    • , Silvia Novello
    • , Niki Karachaliou
    • , Rafael Rosell
    • , Ian Anderson
    • , Nashat Gabrail
    • , John Hrom
    • , Chainarong Limvarapuss
    • , Karin Choquette
    • , Alexander Spira
    • , Raphael Rousseau
    • , Cynthia Voong
    • , Naiyer A Rizvi
    • , Elie Fadel
    • , Mark Frattini
    • , Karin Jooss
    • , Mojca Skoberne
    • , Joshua Francis
    •  & Roman Yelensky
  • Research |

    The relative affinity of T cell receptors for different peptide–MHCs is measured at high throughput, revealing T cell cross-reactivity.

    • Amalie K Bentzen
    • , Lina Such
    • , Kamilla K Jensen
    • , Andrea M Marquard
    • , Leon E Jessen
    • , Natalie J Miller
    • , Candice D Church
    • , Rikke Lyngaa
    • , David M Koelle
    • , Jürgen C Becker
    • , Carsten Linnemann
    • , Ton N M Schumacher
    • , Paolo Marcatili
    • , Paul Nghiem
    • , Morten Nielsen
    •  & Sine R Hadrup
    Nature Biotechnology 36, 1191-1196
  • Research | | open

    Human leukocyte antigens (HLA) are multi-allelic and polymorphic genes that present antigens to immune cells for inducing protective immunity. Here, using systems biology and structural approaches, the authors show that micropolymorphism of three HLA has effects beyond the modulation of antigen diversity.

    • Patricia T. Illing
    • , Phillip Pymm
    • , Nathan P. Croft
    • , Hugo G. Hilton
    • , Vladimir Jojic
    • , Alex S. Han
    • , Juan L. Mendoza
    • , Nicole A. Mifsud
    • , Nadine L. Dudek
    • , James McCluskey
    • , Peter Parham
    • , Jamie Rossjohn
    • , Julian P. Vivian
    •  & Anthony W. Purcell
  • Research | | open

    Acquired resistance is a major problem in cancer immunotherapy. Here the authors report a study of two patients with Merkel cell carcinoma under immunotherapy treatment who develop resistance after deep responses for >1 year and identified a novel mechanism of acquired, gene-specific transcriptional suppression of HLAs.

    • K. G. Paulson
    • , V. Voillet
    • , M. S. McAfee
    • , D. S. Hunter
    • , F. D. Wagener
    • , M. Perdicchio
    • , W. J. Valente
    • , S. J. Koelle
    • , C. D. Church
    • , N. Vandeven
    • , H. Thomas
    • , A. G. Colunga
    • , J. G. Iyer
    • , C. Yee
    • , R. Kulikauskas
    • , D. M. Koelle
    • , R. H. Pierce
    • , J. H. Bielas
    • , P. D. Greenberg
    • , S. Bhatia
    • , R. Gottardo
    • , P. Nghiem
    •  & A. G. Chapuis

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