MHC

The major histocompatibility complex (MHC) is a cluster of genes encoding molecules that are important for lymphocyte activation. MHC molecules bind small fragments of proteins from inside a cell and present these at the cell surface. By scanning MHC molecules, lymphocytes can assess cells for signs of infection or damage.

Latest Research and Reviews

  • Research | | open

    For T cells, functional antigen receptors are selected in the thymus from a pre-selection repertoire by interaction with self MHCs. Here the authors show that specific, non-germline coded features located in the complementarity determining region 3 of the pre-selection antigen receptors are essential for the selection of MHC-restricted repertoire.

    • Jinghua Lu
    • , François Van Laethem
    • , Abhisek Bhattacharya
    • , Marco Craveiro
    • , Ingrid Saba
    • , Jonathan Chu
    • , Nicholas C. Love
    • , Anastasia Tikhonova
    • , Sergei Radaev
    • , Xiaoping Sun
    • , Annette Ko
    • , Tomer Arnon
    • , Eric Shifrut
    • , Nir Friedman
    • , Nan-Ping Weng
    • , Alfred Singer
    •  & Peter D. Sun
  • Research | | open

    Anti-human leukocyte antigen (HLA) antibodies are important mediators of alloresponses, but structural insights on antibody:HLA interaction are still lacking. Here the authors provide a 2.4 Å structure of antibody:HLA complex, and also analyse HLA features important for other HLA-interacting molecules, to enhance our understanding of alloimmunity.

    • Yue Gu
    • , Yee Hwa Wong
    • , Chong Wai Liew
    • , Conrad E. Z. Chan
    • , Tanusya M. Murali
    • , Jiawei Yap
    • , Chien Tei Too
    • , Kiren Purushotorman
    • , Maryam Hamidinia
    • , Abbas El Sahili
    • , Angeline T. H. Goh
    • , Rachel Z. C. Teo
    • , Kathryn J. Wood
    • , Brendon J. Hanson
    • , Nicholas R. J. Gascoigne
    • , Julien Lescar
    • , Anantharaman Vathsala
    •  & Paul A. MacAry
  • Research |

    Regulatory T cells suppress target cells through diverse mechanisms. Shevach and colleagues demonstrate that regulatory T cells in vivo strip complexes of cognate peptide and major histocompatibility complex class II from dendritic cells and thereby help to maintain immune homeostasis.

    • Billur Akkaya
    • , Yoshihiro Oya
    • , Munir Akkaya
    • , Jafar Al Souz
    • , Amanda H. Holstein
    • , Olena Kamenyeva
    • , Juraj Kabat
    • , Ryutaro Matsumura
    • , David W. Dorward
    • , Deborah D. Glass
    •  & Ethan M. Shevach
    Nature Immunology 20, 218-231
  • Research |

    Neoantigen prediction from clinical samples is improved using a neural network model trained on a large HLA peptide and genomic tumor dataset.

    • Brendan Bulik-Sullivan
    • , Jennifer Busby
    • , Christine D Palmer
    • , Matthew J Davis
    • , Tyler Murphy
    • , Andrew Clark
    • , Michele Busby
    • , Fujiko Duke
    • , Aaron Yang
    • , Lauren Young
    • , Noelle C Ojo
    • , Kamilah Caldwell
    • , Jesse Abhyankar
    • , Thomas Boucher
    • , Meghan G Hart
    • , Vladimir Makarov
    • , Vincent Thomas De Montpreville
    • , Olaf Mercier
    • , Timothy A Chan
    • , Giorgio Scagliotti
    • , Paolo Bironzo
    • , Silvia Novello
    • , Niki Karachaliou
    • , Rafael Rosell
    • , Ian Anderson
    • , Nashat Gabrail
    • , John Hrom
    • , Chainarong Limvarapuss
    • , Karin Choquette
    • , Alexander Spira
    • , Raphael Rousseau
    • , Cynthia Voong
    • , Naiyer A Rizvi
    • , Elie Fadel
    • , Mark Frattini
    • , Karin Jooss
    • , Mojca Skoberne
    • , Joshua Francis
    •  & Roman Yelensky
  • Research |

    The relative affinity of T cell receptors for different peptide–MHCs is measured at high throughput, revealing T cell cross-reactivity.

    • Amalie K Bentzen
    • , Lina Such
    • , Kamilla K Jensen
    • , Andrea M Marquard
    • , Leon E Jessen
    • , Natalie J Miller
    • , Candice D Church
    • , Rikke Lyngaa
    • , David M Koelle
    • , Jürgen C Becker
    • , Carsten Linnemann
    • , Ton N M Schumacher
    • , Paolo Marcatili
    • , Paul Nghiem
    • , Morten Nielsen
    •  & Sine R Hadrup
    Nature Biotechnology 36, 1191-1196

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