MHC class I

MHC class I molecules are expressed by all nucleated cells of the body. They bind small fragments of protein from inside a cell and present these at the cell surface. CD8-positive T cells and NK cells can detect infected or damaged cells by scanning MHC class I molecules.

Latest Research and Reviews

  • Research | | open

    Anti-human leukocyte antigen (HLA) antibodies are important mediators of alloresponses, but structural insights on antibody:HLA interaction are still lacking. Here the authors provide a 2.4 Å structure of antibody:HLA complex, and also analyse HLA features important for other HLA-interacting molecules, to enhance our understanding of alloimmunity.

    • Yue Gu
    • , Yee Hwa Wong
    • , Chong Wai Liew
    • , Conrad E. Z. Chan
    • , Tanusya M. Murali
    • , Jiawei Yap
    • , Chien Tei Too
    • , Kiren Purushotorman
    • , Maryam Hamidinia
    • , Abbas El Sahili
    • , Angeline T. H. Goh
    • , Rachel Z. C. Teo
    • , Kathryn J. Wood
    • , Brendon J. Hanson
    • , Nicholas R. J. Gascoigne
    • , Julien Lescar
    • , Anantharaman Vathsala
    •  & Paul A. MacAry
  • Research |

    Neoantigen prediction from clinical samples is improved using a neural network model trained on a large HLA peptide and genomic tumor dataset.

    • Brendan Bulik-Sullivan
    • , Jennifer Busby
    • , Christine D Palmer
    • , Matthew J Davis
    • , Tyler Murphy
    • , Andrew Clark
    • , Michele Busby
    • , Fujiko Duke
    • , Aaron Yang
    • , Lauren Young
    • , Noelle C Ojo
    • , Kamilah Caldwell
    • , Jesse Abhyankar
    • , Thomas Boucher
    • , Meghan G Hart
    • , Vladimir Makarov
    • , Vincent Thomas De Montpreville
    • , Olaf Mercier
    • , Timothy A Chan
    • , Giorgio Scagliotti
    • , Paolo Bironzo
    • , Silvia Novello
    • , Niki Karachaliou
    • , Rafael Rosell
    • , Ian Anderson
    • , Nashat Gabrail
    • , John Hrom
    • , Chainarong Limvarapuss
    • , Karin Choquette
    • , Alexander Spira
    • , Raphael Rousseau
    • , Cynthia Voong
    • , Naiyer A Rizvi
    • , Elie Fadel
    • , Mark Frattini
    • , Karin Jooss
    • , Mojca Skoberne
    • , Joshua Francis
    •  & Roman Yelensky
  • Research |

    The relative affinity of T cell receptors for different peptide–MHCs is measured at high throughput, revealing T cell cross-reactivity.

    • Amalie K Bentzen
    • , Lina Such
    • , Kamilla K Jensen
    • , Andrea M Marquard
    • , Leon E Jessen
    • , Natalie J Miller
    • , Candice D Church
    • , Rikke Lyngaa
    • , David M Koelle
    • , Jürgen C Becker
    • , Carsten Linnemann
    • , Ton N M Schumacher
    • , Paolo Marcatili
    • , Paul Nghiem
    • , Morten Nielsen
    •  & Sine R Hadrup
    Nature Biotechnology 36, 1191-1196
  • Research | | open

    Human leukocyte antigens (HLA) are multi-allelic and polymorphic genes that present antigens to immune cells for inducing protective immunity. Here, using systems biology and structural approaches, the authors show that micropolymorphism of three HLA has effects beyond the modulation of antigen diversity.

    • Patricia T. Illing
    • , Phillip Pymm
    • , Nathan P. Croft
    • , Hugo G. Hilton
    • , Vladimir Jojic
    • , Alex S. Han
    • , Juan L. Mendoza
    • , Nicole A. Mifsud
    • , Nadine L. Dudek
    • , James McCluskey
    • , Peter Parham
    • , Jamie Rossjohn
    • , Julian P. Vivian
    •  & Anthony W. Purcell
  • Reviews |

    This Review explores the mechanistic links underlying the associations between HLA and kidney diseases. The authors discuss how these links might provide insights into disease pathogenesis and describe the clinical implications of these insights.

    • Kate J. Robson
    • , Joshua D. Ooi
    • , Stephen R. Holdsworth
    • , Jamie Rossjohn
    •  & A. Richard Kitching
  • Research | | open

    Human leucocyte antigen E (HLA-E) directly engages NK cells but also presents antigen to CD8+ T cells. Here the authors show crystal structures of HLA-E in complex with peptides derived from HIV and Mycobacterium tuberculosis, and describe binding conformations, the positional impact of residues involved and discuss implications for functional presentation to CD8+ T cells.

    • Lucy C. Walters
    • , Karl Harlos
    • , Simon Brackenridge
    • , Daniel Rozbesky
    • , Jordan R. Barrett
    • , Vitul Jain
    • , Thomas S. Walter
    • , Chris A. O’Callaghan
    • , Persephone Borrow
    • , Mireille Toebes
    • , Scott G. Hansen
    • , Jonah B Sacha
    • , Shaheed Abdulhaqq
    • , Justin M. Greene
    • , Klaus Früh
    • , Emily Marshall
    • , Louis J. Picker
    • , E. Yvonne Jones
    • , Andrew J. McMichael
    •  & Geraldine M. Gillespie

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