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Methylation analysis is the study of chromosomal patterns of DNA or histone modification by methyl groups. The cytosine (C) base in DNA and lysine residue in histone tails can be methylated. Methylation constitutes an epigenetic mark because its location can affect the regulation of gene expression in a heritable fashion.
The presence of multiple functional m6A modification sites on diverse HIV-1 RNA transcripts suggests a strategy to provide additional stability and resilience to HIV-1 replication.
Here the authors show that TET dioxygenases, the erasers of DNA methylation, use a self-limiting mechanism via their LCD domain to ensure adaptable methylome status and protect the genome from excessive oxidative methylation.
DNA methylation patterns that are associated with disease can reveal genes involved in disease etiology. Here, the authors identify blood DNA methylation signatures that are associated with bronchiolitis severity and play important roles in tissues, cells, and pathways.
A metagenomic approach to identifying the sources of N6-methyldeoxyadenine (6mA) in eukaryotic DNA found no evidence of high 6mA abundances in sampled eukaryotes.
