Synthetic chemistry methodology

Synthetic chemistry methodology refers to the methods used for the synthesis of chemical compounds.

Latest Research and Reviews

News and Comment

  • Comments and Opinion |

    Radical intermediates are key species in many chemical transformations. Recent advances have provided a new suite of selective radical alkylation reactions. This Comment highlights pioneering studies using alkyl amines that act as radical precursors in a number of catalytic processes by their conversion to alkylpyridinium salts.

    • Duanyang Kong
    • , Patrick J. Moon
    •  & Rylan J. Lundgren
    Nature Catalysis 2, 473-476
  • News and Views |

    The direct formation of C–N bonds onto arenes provides a simple route to synthesize a variety of important products. Now, formation of a highly polarized, aminium radical cation enables direct C–H amination, allowing the coupling of an exceptionally broad range of alkyl amines and arenes.

    • David Nagib
    Nature Chemistry 11, 396-398
  • News and Views |

    The asymmetric synthesis of chiral γ-lactams is difficult and laborious; typically requiring pre-functionalization of starting materials. Now, a highly efficient alternative approach employing direct C−H amidation via chiral hydrogen-bond-donor catalysts has been developed.

    • Tong-De Tan
    •  & Long-Wu Ye
    Nature Catalysis 2, 182-183
  • Research Highlights |

    Careful reaction design has enabled the use of single electron transfer reagent samarium diiodide in substoichiometric amounts to catalyse radical cyclizations.

    • Stephen G. Davey