Metastasis is the spread of cancer to a part of the body distant from the original primary cancer. This occurs through the transfer of malignant or cancerous cells via lymph or blood. The new occurrences of cancer are called metastases.

Latest Research and Reviews

News and Comment

  • Research Highlights |

    Gkountela et al. have identified that circulating tumour cell (CTC) clusters from patients and mouse models with breast cancer have a distinct DNA methylation profile from that of single CTCs, which together with the phenotypic difference represent a targetable therapeutic vulnerability of metastasis.

    • Anna Dart
  • Research Highlights |

    Keklikoglou et al. show that, in mouse models of chemoresistant breast cancer, paclitaxel and doxorubicin trigger the production of tumour-derived extracellular vesicles with pro-metastatic properties that are dependent on annexin A6.

    • Katharine H. Wrighton
  • News and Views |

    It is commonly accepted that disseminated tumour cells survive cytotoxic chemotherapy because they are not proliferating. A new study now finds that, in contrast to this long-standing concept, both dormant and proliferative cancer cells can be protected from chemotherapy when they reside at the perivascular niche.

    • Melanie Werner-Klein
    •  & Christoph A. Klein
    Nature Cell Biology 21, 117-119
  • Research Highlights |

    Wang et al. demonstrate that increased flux of calcium derived from osteogenic cells into cancer cells promotes early-stage bone colonization. Calcium signalling in cancer cells can be targeted by arsenic trioxide, thereby reducing bone metastasis progression.

    • Ulrike Harjes