Metabolism refers to the chemical reactions that occur within an organism to sustain life. The reactions are divided into two categories: catabolism (the breakdown of organic matter to produce energy); and anabolism (the construction of molecules from smaller units).


Latest Research and Reviews

News and Comment

  • News and Views |

    The SONAR trial reports that treatment with the selective endothelin A receptor antagonist atrasentan reduced the risk of renal events in patients with diabetes and chronic kidney disease. This study was designed to select patients who were likely to benefit from the therapy and minimize the risk of adverse effects.

    • Jennifer S. Pollock
    •  & David M. Pollock
  • News and Views |

    Tests of whether a range of gut bacteria can metabolize a diverse group of drugs has revealed that all the microbes metabolized some drugs and that more than half of the drugs were metabolized.

    • Kim Lewis
    •  & Philip Strandwitz
  • Research Highlights |

    Ptgds-expressing neurons in the preoptic area of anterior hypothalamus detect increases in brain temperature and reduce core body temperature via increased production of prostaglandin D2.

    • Isobel Leake
  • News and Views |

    Lifestyle interventions in patients with prediabetes can delay the onset of type 2 diabetes mellitus, but long-term data on diabetes complications are lacking. A new report from the Da Qing Study provides data on the effect of lifestyle interventions on diabetes mellitus complications and mortality in patients with prediabetes who were followed up for 30 years.

    • Samuel Dagogo-Jack
  • Research Highlights |

    A new study in Science identifies strong selective pressure on mitochondrial DNA during transmission through the female germ line, as well as an interplay with the nuclear genome that shapes mitochondrial genetic variation.

    • Darren J. Burgess