Metabolic bone disease

Metabolic bone disease describes a diverse group of disorders of bone metabolism, most commonly caused by abnormalities of minerals (such as calcium or phosphorous) or vitamin D.

Latest Research and Reviews

  • Research | | open

    Estrogen promotes negative energy balance and preserves skeletal physiology. Here the authors show that loss of estrogen signalling after ablating estrogen receptor alpha (ERa) in specific hypothalamic neuronal populations leads to a marked sex-dependent increase in bone mass in female mice.

    • Candice B. Herber
    • , William C. Krause
    • , Liping Wang
    • , James R. Bayrer
    • , Alfred Li
    • , Matthew Schmitz
    • , Aaron Fields
    • , Breanna Ford
    • , Zhi Zhang
    • , Michelle S. Reid
    • , Daniel K. Nomura
    • , Robert A. Nissenson
    • , Stephanie M. Correa
    •  & Holly A. Ingraham
  • Research |

    Transferrin receptor 2 (Trf2) is known to regulate iron homeostasis through its action in the liver. Here the authors report a previously unrecognised role of Trf2 in regulating bone homeostasis mediated by modulation of BMP signalling specifically on osteoblasts.

    • Martina Rauner
    • , Ulrike Baschant
    • , Antonella Roetto
    • , Rosa Maria Pellegrino
    • , Sandra Rother
    • , Juliane Salbach-Hirsch
    • , Heike Weidner
    • , Vera Hintze
    • , Graeme Campbell
    • , Andreas Petzold
    • , Regis Lemaitre
    • , Ian Henry
    • , Teresita Bellido
    • , Igor Theurl
    • , Sandro Altamura
    • , Silvia Colucci
    • , Martina U. Muckenthaler
    • , Georg Schett
    • , Davide S. K. Komla-Ebri
    • , J. H. Duncan Bassett
    • , Graham R. Williams
    • , Uwe Platzbecker
    •  & Lorenz C. Hofbauer
    Nature Metabolism 1, 111-124
  • Research |

    Genome-wide association analyses identify 301 new loci influencing bone mineral density and 13 loci influencing fracture risk. Integrative analyses of epigenomic data and mouse knockout phenotypes provide additional insights into osteoporosis pathophysiology.

    • John A. Morris
    • , John P. Kemp
    • , Scott E. Youlten
    • , Laetitia Laurent
    • , John G. Logan
    • , Ryan C. Chai
    • , Nicholas A. Vulpescu
    • , Vincenzo Forgetta
    • , Aaron Kleinman
    • , Sindhu T. Mohanty
    • , C. Marcelo Sergio
    • , Julian Quinn
    • , Loan Nguyen-Yamamoto
    • , Aimee-Lee Luco
    • , Jinchu Vijay
    • , Marie-Michelle Simon
    • , Albena Pramatarova
    • , Carolina Medina-Gomez
    • , Katerina Trajanoska
    • , Elena J. Ghirardello
    • , Natalie C. Butterfield
    • , Katharine F. Curry
    • , Victoria D. Leitch
    • , Penny C. Sparkes
    • , Anne-Tounsia Adoum
    • , Naila S. Mannan
    • , Davide S. K. Komla-Ebri
    • , Andrea S. Pollard
    • , Hannah F. Dewhurst
    • , Thomas A. D. Hassall
    • , Michael-John G. Beltejar
    • , Michelle Agee
    • , Babak Alipanahi
    • , Adam Auton
    • , Robert K. Bell
    • , Katarzyna Bryc
    • , Sarah L. Elson
    • , Pierre Fontanillas
    • , Nicholas A. Furlotte
    • , Jennifer C. McCreight
    • , Karen E. Huber
    • , Nadia K. Litterman
    • , Matthew H. McIntyre
    • , Joanna L. Mountain
    • , Elizabeth S. Noblin
    • , Carrie A. M. Northover
    • , Steven J. Pitts
    • , J. Fah Sathirapongsasuti
    • , Olga V. Sazonova
    • , Janie F. Shelton
    • , Suyash Shringarpure
    • , Chao Tian
    • , Joyce Y. Tung
    • , Vladimir Vacic
    • , Catherine H. Wilson
    • , Douglas J. Adams
    • , Suzanne M. Vaillancourt
    • , Stephen Kaptoge
    • , Paul Baldock
    • , Cyrus Cooper
    • , Jonathan Reeve
    • , Evangelia E. Ntzani
    • , Evangelos Evangelou
    • , Claes Ohlsson
    • , David Karasik
    • , Fernando Rivadeneira
    • , Douglas P. Kiel
    • , Jonathan H. Tobias
    • , Celia L. Gregson
    • , Nicholas C. Harvey
    • , Elin Grundberg
    • , David Goltzman
    • , David J. Adams
    • , Christopher J. Lelliott
    • , David A. Hinds
    • , Cheryl L. Ackert-Bicknell
    • , Yi-Hsiang Hsu
    • , Matthew T. Maurano
    • , Peter I. Croucher
    • , Graham R. Williams
    • , J. H. Duncan Bassett
    • , David M. Evans
    •  & J. Brent Richards
    Nature Genetics 51, 258-266

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