Membranoproliferative glomerulonephritis

Membranoproliferative glomerulonephritis is a rare kidney disorder characterized by mesangial cell proliferation and structural changes in glomerular capillary walls. The disorder can be classified into various subtypes based on characteristic abnormal ultrastructures and immune deposits in biopsy samples.

Latest Research and Reviews

  • Reviews |

    This Review presents our current understanding of C3 glomerulopathy. Smith et al. discuss the histopathological diagnosis and the crucial pathogenic role of complement dysregulation. Genetic and acquired drivers of C3 glomerulopathy, potential biomarkers and available treatments are highlighted.

    • Richard J. H. Smith
    • , Gerald B. Appel
    • , Anna M. Blom
    • , H. Terence Cook
    • , Vivette D D’Agati
    • , Fadi Fakhouri
    • , Véronique Fremeaux-Bacchi
    • , Mihály Józsi
    • , David Kavanagh
    • , John D. Lambris
    • , Marina Noris
    • , Matthew C. Pickering
    • , Giuseppe Remuzzi
    • , Santiago Rodriguez de Córdoba
    • , Sanjeev Sethi
    • , Johan Van der Vlag
    • , Peter F. Zipfel
    •  & Carla M. Nester
  • Reviews |

    Neutrophils are crucial regulators of the innate immune response and act as a first line of defence against invading microorganisms. To target microorganisms, neutrophils release extracellular structures called neutrophil extracellular traps (NETs), which externalize key autoantigens. In this Review, Gupta and Kaplan explore the contribution of neutrophils and NETs to the pathophysiology of systemic autoimmune disorders that can affect the kidneys, and discuss neutrophils as novel therapeutic targets for these diseases.

    • Sarthak Gupta
    •  & Mariana J. Kaplan
  • Reviews |

    Renal involvement in primary Sjögren syndrome (pSS) is a rare complication, but regular screening is required for early detection and prevention of progression to chronic kidney disease. In this Review, Hélène François and Xavier Mariette discuss the most frequent renal complications that can occur in pSS, namely tubulointerstitial nephritis and membranoproliferative glomerular nephritis. They outline the pathophysiology of these complications, the differential diagnoses, and current treatment options.

    • Hélène François
    •  & Xavier Mariette
  • Reviews |

    Insights into the pathogenesis of membranoproliferative glomerulonephritis (MPGN) have transformed our understanding of the processes that can lead to the morphological appearance of this pattern of injury. It is now recognized that many cases of MPGN are characterized by the deposition of the complement component C3 in glomeruli without immunoglobulin deposition; this group of diseases is now referred to as C3 glomerulopathies. In this Review, Cook and Pickering discuss the morphological features of MPGN and their different associated pathological processes, in addition to the histological features of C3 glomerulopathies.

    • H. Terence Cook
    •  & Matthew C. Pickering

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