Medical research

Definition

Medical research involves research in a wide range of fields, such as biology, chemistry, pharmacology and toxicology with the goal of developing new medicines or medical procedures or improving the application of those already available. It can be viewed as encompassing preclinical research (for example, in cellular systems and animal models) and clinical research (for example, clinical trials).

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Latest Research and Reviews

  • Reviews |

    The causes of migraine remain unknown despite the high prevalence and societal burden of this disorder. Here, the authors highlight how advances in imaging and genetic studies of migraine provide insights into the underlying mechanisms of this disorder; furthermore, they discuss the potential for genetic and imaging biomarkers to improve our ability to prevent and treat migraine attacks.

    • Dale R. Nyholt
    • , David Borsook
    •  & Lyn R. Griffiths
  • Research |

    Quantitive microbiome profiling reveals that total microbial load is an important determinant of enterotypes and may be a key driver of microbiota alterations in patients with Crohn’s disease.

    • Doris Vandeputte
    • , Gunter Kathagen
    • , Kevin D’hoe
    • , Sara Vieira-Silva
    • , Mireia Valles-Colomer
    • , João Sabino
    • , Jun Wang
    • , Raul Y. Tito
    • , Lindsey De Commer
    • , Youssef Darzi
    • , Séverine Vermeire
    • , Gwen Falony
    •  & Jeroen Raes
  • Research |

    A high-resolution structure of the human ribosome determined by cryo-electron microscopy visualizes numerous RNA modifications that are concentrated at functional sites with an extended shell, and suggests the possibility of designing more specific ribosome-targeting drugs.

    • S. Kundhavai Natchiar
    • , Alexander G. Myasnikov
    • , Hanna Kratzat
    • , Isabelle Hazemann
    •  & Bruno P. Klaholz
  • Research |

    High salt intake changed the gut microbiome and increased TH17 cell numbers in mice, and reduced intestinal survival of Lactobacillus species, increased the number of TH17 cells and increased blood pressure in humans.

    • Nicola Wilck
    • , Mariana G. Matus
    • , Sean M. Kearney
    • , Scott W. Olesen
    • , Kristoffer Forslund
    • , Hendrik Bartolomaeus
    • , Stefanie Haase
    • , Anja Mähler
    • , András Balogh
    • , Lajos Markó
    • , Olga Vvedenskaya
    • , Friedrich H. Kleiner
    • , Dmitry Tsvetkov
    • , Lars Klug
    • , Paul I. Costea
    • , Shinichi Sunagawa
    • , Lisa Maier
    • , Natalia Rakova
    • , Valentin Schatz
    • , Patrick Neubert
    • , Christian Frätzer
    • , Alexander Krannich
    • , Maik Gollasch
    • , Diana A. Grohme
    • , Beatriz F. Côrte-Real
    • , Roman G. Gerlach
    • , Marijana Basic
    • , Athanasios Typas
    • , Chuan Wu
    • , Jens M. Titze
    • , Jonathan Jantsch
    • , Michael Boschmann
    • , Ralf Dechend
    • , Markus Kleinewietfeld
    • , Stefan Kempa
    • , Peer Bork
    • , Ralf A. Linker
    • , Eric J. Alm
    •  & Dominik N. Müller
  • Research | | open

    CD4+ T cells secreting interleukin-17 (TH17) have diverse functions in modulating autoimmune diseases. Here the authors show via transcriptome analyses that a subset of human TH 17 co-expressing interferon-γ (TH1/17) has a molecular signature similar to “pathogenic” mouse TH 17 but distinct from “non-pathogenic” mouse TH 17.

    • Dan Hu
    • , Samuele Notarbartolo
    • , Tom Croonenborghs
    • , Bonny Patel
    • , Ron Cialic
    • , Tun-Hsiang Yang
    • , Dominik Aschenbrenner
    • , Karin M. Andersson
    • , Marco Gattorno
    • , Minh Pham
    • , Pia Kivisakk
    • , Isabelle V. Pierre
    • , Youjin Lee
    • , Karun Kiani
    • , Maria Bokarewa
    • , Emily Tjon
    • , Nathalie Pochet
    • , Federica Sallusto
    • , Vijay K. Kuchroo
    •  & Howard L. Weiner

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