Mechanotransduction

Definition

Mechanotransduction refers to the processes through which cells sense and respond to mechanical stimuli by converting them to biochemical signals that elicit specific cellular responses.

Latest Research and Reviews

  • Research | | open

    The arterial wall is subjected to mechanical forces that modulate endothelial cell responses. Here, Mack and colleagues identify a novel role for Notch1 as a mechanosensor in adult arteries, where it ensures junctional integrity through modulation of calcium signalling and limits atherosclerosis.

    • Julia J. Mack
    • , Thiago S. Mosqueiro
    • , Brian J. Archer
    • , William M. Jones
    • , Hannah Sunshine
    • , Guido C. Faas
    • , Anais Briot
    • , Raquel L. Aragón
    • , Trent Su
    • , Milagros C. Romay
    • , Austin I. McDonald
    • , Cheng-Hsiang Kuo
    • , Carlos O. Lizama
    • , Timothy F. Lane
    • , Ann C. Zovein
    • , Yun Fang
    • , Elizabeth J. Tarling
    • , Thomas Q. de Aguiar Vallim
    • , Mohamad Navab
    • , Alan M. Fogelman
    • , Louis S. Bouchard
    •  & M. Luisa Iruela-Arispe
  • Reviews |

    Physical cues regulate stem cell fate and function during embryonic development and in adult tissues. The biophysical and biochemical properties of the stem cell microenvironment can be precisely manipulated using synthetic niches, which provide key insights into how mechanical stimuli regulate stem cell function and can be used to maintain and guide stem cells for regenerative therapies.

    • Kyle H. Vining
    •  & David J. Mooney
  • Reviews |

    Coordinated movements of cell collectives are important for morphogenesis, tissue regeneration and cancer cell dissemination. Recent studies, mainly using novel in vitro approaches, have provided new insights into the mechanisms governing this multicellular coordination, highlighting the key role of the mechanosensitivity of adherens junctions and mechanical cell–cell coupling in collective cell behaviours.

    • Benoit Ladoux
    •  & René-Marc Mège
  • Research | | open

    Mechanical forces play a crucial role during morphogenesis, but how these are sensed and transduced in vivo is not fully understood. Here the authors apply a FRET tension sensor to live zebrafish and study changes in VE-cadherin tension at endothelial cell-cell junctions during arterial maturation.

    • Anne Karine Lagendijk
    • , Guillermo A. Gomez
    • , Sungmin Baek
    • , Daniel Hesselson
    • , William E. Hughes
    • , Scott Paterson
    • , Daniel E. Conway
    • , Heinz-Georg Belting
    • , Markus Affolter
    • , Kelly A. Smith
    • , Martin A. Schwartz
    • , Alpha S. Yap
    •  & Benjamin M. Hogan

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