Measles virus

Definition

An infectious agent belonging to the virus family Paramyxoviridae that causes an infection of the respiratory system that is characterized by a maculopapular rash on the skin. The infection mostly occurs in children but is preventable by vaccination.

Latest Research and Reviews

  • Reviews |

    Measles is an infectious disease caused by the measles virus. In this Primer, Rota et al. cover the pathophysiology and management options, with a focus on the strategies to eliminate endemic transmission of the measles virus by achieving a high level of vaccination coverage

    • Paul A. Rota
    • , William J. Moss
    • , Makoto Takeda
    • , Rik L. de Swart
    • , Kimberly M. Thompson
    •  & James L. Goodson
  • Research |

    Measles virus hemagglutinin (MVH) can bind to different cell surface receptors in the human host. CD46, the first identified MVH receptor, is used mainly by vaccine strains, whereas clinical strains can use SLAM on macrophages and dendritic cells and nectin-4 on epithelial cells. The crystal structure of MVH in complex with the outermost ectodomain of nectin-4 is now presented, revealing a potential target site for drug development.

    • Xiaoai Zhang
    • , Guangwen Lu
    • , Jianxun Qi
    • , Yan Li
    • , Yan He
    • , Xiang Xu
    • , Jia Shi
    • , Catherine W-H Zhang
    • , Jinghua Yan
    •  & George F Gao
  • Research |

    Nectin-4 is identified as a receptor for measles virus on epithelial cells, and measles virus might use nectin-4 for emergence in the airways.

    • Michael D. Mühlebach
    • , Mathieu Mateo
    • , Patrick L. Sinn
    • , Steffen Prüfer
    • , Katharina M. Uhlig
    • , Vincent H. J. Leonard
    • , Chanakha K. Navaratnarajah
    • , Marie Frenzke
    • , Xiao X. Wong
    • , Bevan Sawatsky
    • , Shyam Ramachandran
    • , Paul B. McCray
    • , Klaus Cichutek
    • , Veronika von Messling
    • , Marc Lopez
    •  & Roberto Cattaneo
    Nature 480, 530–533
  • Research |

    The measles virus hemagglutinin (MVH) promotes viral attachment to host cells via interaction with signaling lymphocyte activation molecule (SLAM). Now the crystal structure of MVH head domain in complex with the distal domain of SLAM, together with functional work, reveals the details of this interaction and explains the effectiveness of the currently used vaccine.

    • Takao Hashiguchi
    • , Toyoyuki Ose
    • , Marie Kubota
    • , Nobuo Maita
    • , Jun Kamishikiryo
    • , Katsumi Maenaka
    •  & Yusuke Yanagi

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