Marginal zone B cells

Marginal zone B cells are a specialized population of B cells that are located in the marginal zone of the spleen. They secrete antibodies that help to protect against blood-borne viruses and bacteria.

Latest Research and Reviews

  • Research | | open

    Marginal zone B (MZB) cells shuttle between the marginal zone and lymphoid follicle to capture and present peripheral blood antigens. Here the authors show that shear force, such as blood flow from the sinus around the follicle, is a directional cue that induces MZB migration on ICAM-1, and that S1P signaling inhibits this directional migration.

    • Kerry Tedford
    • , Michael Steiner
    • , Stanislav Koshutin
    • , Karin Richter
    • , Laura Tech
    • , Yannik Eggers
    • , Inga Jansing
    • , Kerstin Schilling
    • , Anja Erika Hauser
    • , Mark Korthals
    •  & Klaus-Dieter Fischer
  • Research | | open

    Marginal zone B cells differentiate into plasma cells rapidly in response to T-cell-independent antigens, but how they do so is not clear. Here the authors show TACI cooperates with TLR signalling to drive mTOR activity and subsequent class switching and plasmablast differentiation.

    • Jordi Sintes
    • , Maurizio Gentile
    • , Shuling Zhang
    • , Yolanda Garcia-Carmona
    • , Giuliana Magri
    • , Linda Cassis
    • , Daniel Segura-Garzón
    • , Alessandra Ciociola
    • , Emilie K. Grasset
    • , Sabrina Bascones
    • , Laura Comerma
    • , Marc Pybus
    • , David Lligé
    • , Irene Puga
    • , Cindy Gutzeit
    • , Bing He
    • , Wendy DuBois
    • , Marta Crespo
    • , Julio Pascual
    • , Anna Mensa
    • , Juan Ignacio Aróstegui
    • , Manel Juan
    • , Jordi Yagüe
    • , Sergi Serrano
    • , Josep Lloreta
    • , Eric Meffre
    • , Michael Hahne
    • , Charlotte Cunningham-Rundles
    • , Beverly A. Mock
    •  & Andrea Cerutti
  • Research |

    Splenic marginal zone B cells suppress atherosclerosis in mice by dampening the proatherogenic T follicular helper response via a PDL1-dependent interaction with T follicular helper cells.

    • Meritxell Nus
    • , Andrew P Sage
    • , Yuning Lu
    • , Leanne Masters
    • , Brian Y H Lam
    • , Stephen Newland
    • , Sandra Weller
    • , Dimitrios Tsiantoulas
    • , Juliette Raffort
    • , Damiënne Marcus
    • , Alison Finigan
    • , Lauren Kitt
    • , Nichola Figg
    • , Reinhold Schirmbeck
    • , Manfred Kneilling
    • , Giles S H Yeo
    • , Christoph J Binder
    • , José Luis de la Pompa
    •  & Ziad Mallat
    Nature Medicine 23, 601-610
  • Research |

    The signaling receptor Notch is required for the generation of marginal zone B cells. Hammad and colleagues show that Notch signaling activates the kinase Taok3 and surface expression of the metalloproteinase ADAM10, which commits transitional B cells to the marginal zone B cell fate.

    • Hamida Hammad
    • , Matthias Vanderkerken
    • , Philippe Pouliot
    • , Kim Deswarte
    • , Wendy Toussaint
    • , Karl Vergote
    • , Lana Vandersarren
    • , Sophie Janssens
    • , Ioanna Ramou
    • , Savvas N Savvides
    • , Jody J Haigh
    • , Rudi Hendriks
    • , Manfred Kopf
    • , Katleen Craessaerts
    • , Bart de Strooper
    • , John F Kearney
    • , Daniel H Conrad
    •  & Bart N Lambrecht
    Nature Immunology 18, 313-320

News and Comment

  • News and Views |

    RNA-binding proteins (RBPs) take control of binary cell-fate 'decisions' and cellular identity in lymphoid organs, as the RBP ZFP36L1 is shown to negatively regulate the stability of the transcription factors KLF2 and IRF8 to control the maintenance, survival and localization of marginal zone B cells.

    • Palaniraja Thandapani
    • , Beatriz Aranda-Orgilles
    •  & Iannis Aifantis
    Nature Immunology 18, 595-597
  • News and Views |

    Small, soluble, ubiquitous ligands are difficult to visualize. Schwab and colleagues have created a functional receptor reporter that gauges the in vivo concentration, location and biological action of sphingolipids.

    • C Colin Brinkman
    •  & Jonathan S Bromberg
    Nature Immunology 16, 1209-1211
  • News and Views |

    Innate lymphoid cells, marginal reticular cells and B cell–helper neutrophils interact to promote antibody secretion by B cells in the marginal zone of the spleen in humans and mice.

    • Gabriel D Victora
    Nature Immunology 15, 313-314