Male factor infertility

Male factor infertility is the failure of a couple to conceive owing to a male-related factor. Male factor infertility can be caused by semen abnormalities (detected on semen analysis) or sexual dysfunction.

Latest Research and Reviews

  • Reviews |

    Male infertility is a multifactorial pathological condition, and its genetic landscape is highly complex. Here, Krausz and Riera-Escamilla describe our current understanding of the genetics of male infertility and the clinical implications of this knowledge.

    • Csilla Krausz
    •  & Antoni Riera-Escamilla
  • Reviews |

    In this Review, Lotti and Maggi discuss the correlations between sexual dysfunction and male infertility, focusing on the associations between reproductive, sexual, psychological, and general health.

    • Francesco Lotti
    •  & Mario Maggi
  • Research | | open

    Asthenozoospermia is a major cause of male infertility, and multiple morphological abnormalities of the flagella (MMAF) is a particularly severe form. Here, using whole-exome sequencing of 78 MMAF patients, the authors identify mutations in two WDR proteins, CFAP43 and CFAP44, and confirm that these proteins are required for flagellogenesis in mouse and Trypanosoma brucei.

    • Charles Coutton
    • , Alexandra S. Vargas
    • , Amir Amiri-Yekta
    • , Zine-Eddine Kherraf
    • , Selima Fourati Ben Mustapha
    • , Pauline Le Tanno
    • , Clémentine Wambergue-Legrand
    • , Thomas Karaouzène
    • , Guillaume Martinez
    • , Serge Crouzy
    • , Abbas Daneshipour
    • , Seyedeh Hanieh Hosseini
    • , Valérie Mitchell
    • , Lazhar Halouani
    • , Ouafi Marrakchi
    • , Mounir Makni
    • , Habib Latrous
    • , Mahmoud Kharouf
    • , Jean-François Deleuze
    • , Anne Boland
    • , Sylviane Hennebicq
    • , Véronique Satre
    • , Pierre-Simon Jouk
    • , Nicolas Thierry-Mieg
    • , Beatrice Conne
    • , Denis Dacheux
    • , Nicolas Landrein
    • , Alain Schmitt
    • , Laurence Stouvenel
    • , Patrick Lorès
    • , Elma El Khouri
    • , Serge P. Bottari
    • , Julien Fauré
    • , Jean-Philippe Wolf
    • , Karin Pernet-Gallay
    • , Jessica Escoffier
    • , Hamid Gourabi
    • , Derrick R. Robinson
    • , Serge Nef
    • , Emmanuel Dulioust
    • , Raoudha Zouari
    • , Mélanie Bonhivers
    • , Aminata Touré
    • , Christophe Arnoult
    •  & Pierre F. Ray
  • Reviews |

    Many emerging opportunities exist for microfluidics in male infertility diagnosis and treatment, and promising microfluidic approaches are under investigation for addressing male infertility. In this Review, the authors describe and discuss these approaches for sperm analysis and selection.

    • Reza Nosrati
    • , Percival J. Graham
    • , Biao Zhang
    • , Jason Riordon
    • , Alexander Lagunov
    • , Thomas G. Hannam
    • , Carlos Escobedo
    • , Keith Jarvi
    •  & David Sinton

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